The Institute of Metabolic and Cardiovascular Diseases (I2MC) develops research to understand the pathophysiological mechanisms involved in common chronic non-communicable diseases: obesity, diabetes, thrombosis, atherosclerosis and diseases of the vessels, heart and kidney.


The Institute of Metabolic and Cardiovascular Diseases (I2MC) was created in 2011 from the merger of pre-existing research units located near the clinical services of the Toulouse Rangueil University Hospital. The I2MC has been renewed in 2021 for a 6-year term by Inserm and the University Toulouse III – Paul Sabatier (UMR 1297). The I2MC is composed of 11 research teams and 7 technological platforms for a total staff of 280 people. Scientists and clinicians work on metabolic risk factors (obesity, diabetes and dyslipidemia) and their cardiovascular complications (vascular diseases, thrombosis, atherosclerosis, heart and kidney failure). The I2MC has recognized expertise in cell biology, mouse models and clinical work supported by skills in lipidomics, genomics, proteomics, animal phenotyping and cellular imaging. The I2MC is at the center of a very active network of local, national and international collaborations. The I2MC offers opportunities to work on major chronic diseases in human health in the highly appreciated environment of Toulouse.









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technological platforms

Parent institutions and partners

Main financial supporters

management team

Trained as a veterinarian, Dominique Langin obtained a Master’s degree and a PhD in France before doing a post-doctoral fellowship at the University of Lund in Sweden and embarking on a scientific career at the CNRS and Inserm. He is currently a University Professor – Hospital Practitioner at the University Hospital of Toulouse and at the University Toulouse III – Paul Sabatier. His research combines cellular, animal and human studies. He has participated in national and European research projects and obtained a Synergy grant from the European Research Council in 2020. He has dedicated his scientific career to the study of the biology of adipose tissue, obesity and diabetes with a particular focus on fatty acid metabolism. He has received several awards including the Friedrich Wassermann Life Time Achievement Award from the European Association for the Study of Obesity in 2011 and the Labbé Prize from the French Academy of Sciences in 2019. In 2021, he was named a member of the “Institut Universitaire de France“.
Dominique LANGIN

Director of the Institute of Metabolic and Cardiovascular Diseases (I2MC)


Deputy Director


Administrative Director


Project Manager


Project Manager


Project Manager

L’organisation de l’I2MC

Research teams

Technological platforms

Administration and support services

Laboratory Council

Scientific advisory board

An independent Strategic Scientific Committee (SAB), composed of experts in the Institute’s scientific fields, both French and foreign, is appointed by the Director of the I2MC. Its objective is to examine the Institute’s strategies, its organization and that of its teams in order to prepare and optimize each evaluation by the national supervisory authorities. The SAB advises the director and the team leaders in order to improve the organization of the Institute and its scientific production.


DISEASES explained

Type 2 diabetes

Diabetes is a long-term excess of glucose concentration in the blood (hyperglycemia). In the case of type 2 diabetes, this is caused by a disturbance of the carbohydrate metabolism. Even if it appears gradually and insidiously, the disease has serious consequences, even fatal, in the long term.


Cardiovascular diseases

Cardiovascular diseases (CVDs) are the leading cause of death globally, taking an estimated 17.9 million lives each year. CVDs are a group of disorders of the heart and blood vessels and include coronary heart disease, cerebrovascular disease, rheumatic heart disease and other conditions.

Kidney disease

Kidney failure is the result of the slow evolution of the disease that leads to the destruction of the kidneys. It affects more than 82,000 people in France and requires dialysis or transplantation. In 50% of cases, chronic kidney diseases are the consequence of diabetes or high blood pressure.


Obesity is an excess of body fat and a change in adipose tissue, which can lead to health problems and shorten life expectancy. Its causes are complex. It results from the interplay of several factors – dietary, genetic, epigenetic and environmental – involved in the development and progression of this chronic disease.


Non-profit and patient associations


A.F.E.R.O is the French Association for Study and Research on Obesity. Its aim is to promote scientific exchanges, the dissemination of knowledge and training in the field of biomedical research on obesity. The AFERO can be considered as the learned society of Obesity in France.


French-speaking Society of Nephrology, Dialysis and Transplantation

The mission of the SFNDT is to support the development of nephrology in all its fields, from clinical nephrology to dialysis and renal transplantation, as well as in all dimensions of care, basic research, epidemiological and clinical advances, and education.


French Federation of Cardiology

Created in 1964, the French Federation of Cardiology is an association recognized as being of public utility since 1977. A collective vocation mobilized to reduce cardiovascular diseases.



New review from LIPSIPLAT (B. Payrastre) team in ATVB

PIKfyve-dependent phosphoinositide dynamics in megakaryocyte/platelet granule integrity and platelet functions Auteurs : Manuella Caux, Rana Mansour, Jean-Marie Xuereb, Gaëtan Chicanne, Julien Viaud1, Alicia Vauclard, Frédéric Boal, Bernard Payrastre, Hélène...

External seminar – Dominique MORELLO – June, 21st 11h

Le 21 juin à 11h Dominique MORELLO présentera sa conférence “Du cliché 51 aux vaccins à ARN, pleins feux sur des femmes scientifiques remarquables” dans la salle de conférence de l’I2MC.

XXELLES exhibition at I2MC

L’I2MC accueille dans ses locaux l’exposition XXElles pendant tout le mois de juin. Vous pourrez retrouver 12 portraits de femmes scientifiques toulousaines dans différents lieux de notre Institut.

General assembly of I2MC staff

Le jeudi 23 juin à 11h aura lieu l’Assemblée Générale du centre à l’Amphi C.
Elle sera suivie d’un moment de convivialité autour d’un buffet à la cafétéria.

Optimize the management of your emails

Proposed as part of the quality of life at work week, the objectives of this workshop/seminar are as follows: Limit the time spent reading, writing, sorting emails. Avoid information overload; Reduce media dependency; Reduce stress and pressure at work; Improve...

Garmy-Susini/Prats team obtains FRM-Equipe label

L’équipe « Régulations moléculaires des facteurs (lymph)angiogéniques dans les pathologies vasculaires » dirigée par Barbara Garmy-Susini et Anne-Catherine Prats vient d’obtenir la labélisation FRM-Equipe pour ses travaux portant sur l’étude des ARN non codants dans le cadre du lymphœdème secondaire.

New review from LiMitAging (L. MARTINEZ) in the International Journal of Molecular Sciences

The Interplay of Endothelial P2Y Receptors in Cardiovascular Health: From Vascular Physiology to Pathology Auteurs : Cendrine CABOU et Laurent MARTINEZ Int J Mol Sci. 2022 May 24;23(11):5883. doi: 10.3390/ijms23115883. PMID: 35682562; PMCID: PMC9180512. Abstract The...

I2MC Conference 17th of May at 11h – Thomas MANGEAT

T. Mangeat will present a new versatile and Open Source superresolved microscopy methods based on dynamic speckle for a wide range of biological applications. He will demonstrate the ability to gaining confidence on living intracellular cell nanoscopy on many sensitive and complex biological situations.

3rd meeting of the French Optogenetic Club

23 et 24 Juin , CBI Toulouse Optogenetics is a cell imaging technique that has been gaining momentum over the last decade. Indeed, this technique allows to manipulate the intra-cellular signaling or the fate of proteins in real time on living cells using light....

Scientific day AVIESAN “A walk through uses of AI in experimental biology and bio-medicine”

The aim of this joint day will be to inform the French scientific community about advances in the field of artificial intelligence and its use in biomedical research. It intended at all research actors, scientists, clinicians, academics and private researchers.

logotype i2mc
logotype i2mc

Inserm/UPS UMR 1297 - I2MC Institut des Maladies Métaboliques et Cardiovasculaires

1 avenue Jean Poulhès - BP 84225 - 31432 Toulouse Cedex 4

Tél. : 05 61 32 56 00




Du lundi au vendredi
8h30 - 12h30 / 13h45 -16h45