BIOINFORMATIC

 

Collaborative analysis of biological research results using the latest bioinformatic/biostatistic software. Develop novel computational pipelines for new technologies.

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TEAM

Expertises

EQUIPMENTS

BOOKING/CONTACT

Teams

 
Tous / AllPlateform leaderTechnical staffScientific adviser
Plateform leader

Jason IACOVONI

Engineer

Ignacio GONZALEZ-FUENTES

Principal scientist

Nathalie VIGUERIE

Plateform leader

Jason IACOVONI

PhD, Engineer Inserm

Engineer

Ignacio GONZALEZ-FUENTES

Engineer

Principal scientist

Nathalie VIGUERIE

Researcher

Multiomics in clinic to discover new genes and pathways involved in the pathogenicity of obesity. Scientific coordinator of I2MC Bioinformatics Core Facility. Member of the PHASE Research Division of INRAE. Coordination of JPI HDHL miRDiet project and Genomics Research Line of FP6 DiOGenes Diet, Obesity and Genes project. Teaching activities with functional genomics sessions in Masters

Main domains of expertise
Obesity, adipokines, biomarkers, -omics, network analyses, missing data imputation

SCIENTIFIC COMMITTEE

 

 

Nathalie Viguerie   Email me 
Joost Schanstra   Email me
Marion Aguirrebengoa   Email me
Sébastien Déjean   Email me
Henrik Laurell   Email me
Ignacio Gonzalez-Fuentes    Email me

EXPERTISES

GENOME

Sequence analysis
ChIP-Seq, ATAC-Seq, Hi-C

TRANSCRIPTOME

Microarrays and RNASeq
Single Cell and Spatial
ncRNAs, splicing, circular, antisense

PROTEOME

Differential protein analyses
Cohort and timecourse analyses

CUSTOM

Many collaborative projects have developed novel methods for analyzing new data types and even the creation of software and proprietary results leading to patents and private industry research.

EQUIPMENTS

Workstation

Dual CPU workstation with large memory and dual Xeon architecture. Linux OS and all required system software to run all software required.

Network Attached Storage

Large RAID array of disks to safely store project data during analyses.

Open Source Software

The majority of analyses are carried out with open source software in R from CRAN and bioconductor. The plateau excels at searching the internet and literature in order to find packages as well as functions and methods for the most up to date and scientifically valid software to use for each analysis. In addition, free but closed source software, often from technology manufacturers are also employed as required.

Databases and Public Repositories

Any public resource required to perform a comprehensive analysis can be downloaded and integrated into the analysis pipeline. This includes genome databases, gene annotations, public ‘omic results from repositories and automated enrichment analyses with EnrichR web API with custom ggplot2 figure representations.

 

BOOKING & CONTACT

 

Each project with the Bioinformatics Core is different.

To begin a project, request a meeting by email.

A REQUEST ?

publications

Cardiac sensory afferents modulate susceptibility to anxio-depressive behaviour in a mouse model of chronic heart failure. Kermorgant M, Ben Salem J, Iacovoni JS, Calise D, Dahan L, Guiard BP, Lopez S, Lairez O, Lasbories A, Nasr N, Pavy Le-Traon A, Beaudry F, Senard JM, Arvanitis DN. Acta Physiol (Oxf). 2021. Pubmed

Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors. Lefèvre L, Iacovoni JS, Martini H, Bellière J, Maggiorani D, Dutaur M, Marsal DJ, Decaunes P, Pizzinat N, Mialet-Perez J, Cussac D, Parini A, Douin-Echinard V. Cell Mol Life Sci. 2021.  Pubmed

Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism. Attané C, Estève D, Chaoui K, Iacovoni JS, Corre J, Moutahir M, Valet P, Schiltz O, Reina N, Muller C.Cell Rep. 2020. Pubmed

Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset. Martini H, Iacovoni JS, Maggiorani D, Dutaur M, Marsal DJ, Roncalli J, Itier R, Dambrin C, Pizzinat N, Mialet-Perez J, Cussac D, Parini A, Lefevre L, Douin-Echinard V. Aging Cell. 2019. Pubmed

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures. Clouaire T, Rocher V, Lashgari A, Arnould C, Aguirrebengoa M, Biernacka A, Skrzypczak M, Aymard F, Fongang B, Dojer N, Iacovoni JS, Rowicka M, Ginalski K, Côté J, Legube G. Mol Cell. 2018. Pubmed

News

EndoTreat: research project conducted in partnership with the Toulouse University Hospital (E. Chantalat), INSERM-I2MC (F. Lenfant) and the start-up company Urosphère

EndoTreat: research project conducted in partnership with the Toulouse University Hospital (E. Chantalat), INSERM-I2MC (F. Lenfant) and the start-up company Urosphère

EndoTreat: research project conducted in partnership with the Toulouse University Hospital (E. Chantalat), INSERM-I2MC (F. Lenfant) and the start-up company Urosphère. Creating endometriosis organoids from patients’ lesions to test drug candidates. This is the challenge of the EndoTreat project led by a team from Toulouse.

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THEY ARE SUPPORTING OUR RESEARCH

GenoToul Biostats

GenoToul Biostats

UPS

UPS

Genotoul

Genotoul

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Inserm/UPS UMR 1297 - I2MC Institut des Maladies Métaboliques et Cardiovasculaires

1 avenue Jean Poulhès - BP 84225 - 31432 Toulouse Cedex 4

Tél. : 05 61 32 56 00

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Horaires

Du lundi au vendredi
8h30 - 12h30 / 13h45 -16h45