Équipe K.HNIA

MYOPROTEOS

L’Équipe

 
Tous / AllTeam leaderResearchersTechnical staffStudents
Principal scientist

Karim HNIA

Chercheure

Marie VANDROMME

PhD student

Mathilde VAUCOURT

PhD student

Nesrine HIFDI

Engineer

Marine MARSEILLAC

Principal scientist

Karim HNIA

INSERM researcher

He develops research programs on how PI-metabolism regulate proteostasis in skeletal muscle and implications in muscle diseases such as myopathies and sarcopenia.

Career path
Master and PhD degrees in biochemistry and molecular biology at university of Montpellier (2002-2006), Postdoc position IGBMC, Strasbourg (2007-2011), junior researcher at the IGBMC (2012) and senior researcher at the I2MC (2016-current)..

Main domains of expertise
Phosphoinositides, proteostasis, trafficking, muscle disease and physiology.

Email:karim.hnia@inserm.fr

Tél/Phone:05 31 22 41 42

Twitter:@hnia_karim

Chercheure

Marie VANDROMME

INSERM researcher

Her current research focuses on the contribution of epigenetic mechanisms to the etiology of X-linked myotubular myopathy, a fatal pediatric disease due to mutations in the gene encoding the phosphoinositide 3-phosphatase MTM1.

Career path

Master’s degree and PhD in Biology&Health at University of Montpellier, France. HDR (University Paul Sabatier. 1995-1997 post-doctoral period at the National Institute for Medical Research, London (England). 1995-current INSERM researcher at the CRBM and IGH, Montpellier (1995-1999), at ENS Lyon (2000-2003), LBCMCP and CBI, Toulouse (2004-august 2021), and I2MC (September 2021-current).

Main domains of expertise

Proliferation and differentiation, skeletal muscle, Cancer, Myopathy, Chromatin, Histone modifications and gene expression, Transcription, Cell and molecular biology.

PhD student

Mathilde VAUCOURT

PhD Student

Mathilde Vaucourt studies the involvement of autophagy, more precisely mitophagy, during muscle differentiation using physiological and pathological cell models established by genome editing.

Career path

Research Master in Biology and Health at the Faculty of Science and Technology of Nancy (2022).

Main domains of expertise

Cell biology and biochemistry.

PhD student

Nesrine HIFDI

PhD Student

Nesrine Hifdi studies the role of the ubiquitin ligase Fbxw7 in myogenesis and the link with phosphoinositide metabolism in the context of muscle differentiation using physiological and pathological cell models established by genome editing.

Career path

Master in Biology-Health (specialization in pathophysiology) at the University of Toulouse in 2021.

Main domains of expertise

Cellular and molecular biology, biochemistry of phosphoinositides

Engineer

Marine MARSEILLAC

Engineer

Marine Marseillac is working on the characterization of new PI3Ks inhibitors in different in vitro cellular models.

Career path

Master’s degree in Biology-Health with a specialization in Physiopathology at Paul Sabatier University, Toulouse.

Main domains of expertise

Cellular biology, Molecular biology, Biochemistry.

PROJET 1

Coordinateurs : Karim HNIA,

Par

PROJET 2

Coordinateurs : K. HNIA

PROJET 3

Coordinateur :

publications

Shaping Striated Muscles with Ubiquitin Proteasome System in Health and Disease.
Hnia K, Clausen T, Moog-Lutz C.  Trends Mol Med. 2019 Sep;25(9):760-774.

The MTM1-UBQLN2-HSP complex mediates degradation of misfolded intermediate filaments in skeletal muscle.
Gavriilidis C, Laredj L, Solinhac R, Messaddeq N, Viaud J, Laporte J, Sumara I, Hnia K. 
Nature Cell Biology 2018. Pubmed

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