Françoise LENFANT / CORALIE FONTAINE

Françoise LENFANT

PhD, Director of research, Group leader

Career path

Françoise LENFANT received her PhD in Microbiology from the Institut National des Sciences Appliqués à Toulouse, in 1991. From 1991 to 1994, she worked as a post-doctoral fellow in the field of Molecular Biology at the University of California, USA, then in Toulouse in the field of reproduction and was recruited as a principal investigator at INSERM, Toulouse, in 1997. Since 2005, Francoise LENFANT is a Director of research at the INSERM U1297, working on modulation of Estrogen Receptor in medicine.

Main domains of expertise

Sexual steroids, Estrogen Receptor, reproduction, endothelium, breast cancer, in vivo models.

Coralie FONTAINE

CRCN (research fellow, normal class) at INSERM

Develops research on the impact of estrogen receptor (ER)a modulation on the arterial wall with implications for vascular pathologies such as atherosclerosis.

Career path
D. in biochemistry and molecular biology at the University of Lille (2002-2006), Postdoc at the University of Nice (2007-2008), joined the I2MC in Toulouse in 2008 and was recruited as a research fellow at Inserm in 2010.

Field of expertise 
Nuclear receptor, estrogen, endothelium, in vivo approaches.

Jean-François ARNAL

Jean-Francois ARNAL, Professor of Physiology

Jean-François ARNAL is professor in Physiology at Toulouse 3 University of Medicine and at Toulouse University Hospital since 1997, after a doctorate in medicine (1990), and a doctorate in physiopathology (1993) followed with a post-doctoral internship at the ‘Emory University at Atlanta (1994). He led the team until 2019 studying the structure-function relationships for optimization of Estrogen Receptor Alpha (ERα) modulation in medicine, summarized in the review: Membrane and Nuclear ERα Actions: From Tissue Specificity to Medical Implications. Arnal JF, Lenfant F, Metivier R, Flouriot G, Henrion D, Adlanmerini M, Fontaine C, Gourdy P, Chambon P, Katzenellenbogen B, Katzenellenbogen J. Physiol Rev . 2017 Jul 1; 97 (3): 1045-1087. PMID: 28539435. He is a foreign member of the Royal Academy of Medicine of Belgium (2020). He collaborates with Mithra Pharmaceuticals on Estetrol (E4) in oral contraception He obtained the Lamonica Prize for Cardiology of the Academy of Sciences in 2019. He is also a professor in physiology in PACES / PASS and in the 2nd year of medicine and is co-responsible for the Master resaerch  in physiopathology: from molecular to medical, and prepare future M.D. students in 2nd year of medicine at the INSERM School and at the ” MD-PhD training program ”. Videos M2 level: Role of estrogens in cardiovascular diseases – Jean-François ARNAL – Dec 2018 https://www.youtube.com/watch?v=C_Gq8xIWubM

Marine ADLANMERINI

Post-Doc,  INSERM researcher since Decembre 2021

Career path
Marine ADLANMERINI received her PhD in Physiology at the university of Toulouse (FR) in 2015. From 2016 to 2020, she worked as a post-doctoral fellow in the laboratory of Mitch Lazar in Philadelphie (USA) and then joined I2MC at Toulouse in 2021. She was recruited at the position of CRCN (tenured researcher) at the Inserm in Decembre 2021.

Main domains of expertise
Nuclear receptor (ER and REV-ERB), estrogen, circadian rhythms, metabolism, in vivo approaches.

Elodie CHANTELAT

Xavier GAME

Emmanuelle NOIRRIT-ESCLASSANC

Lecturer – Hospital practitioner

Career path

Master of Biological and Medical Sciences at the University Paul Sabatier Toulouse III (1995-1998). State Diploma of Doctor of Dental Surgery (1999). Diploma of Advanced Studies in Social Anthropology and History of Europe (École des Hautes Études en Sciences Sociales) (2000). PhD (LU Interface Biomaterials Biological Tissues) (2009). Joined in 2015.

Areas of expertise
Her research focuses on the study of pathophysiological mechanisms involved in the thromboembolic and bone effects of estrogens in the context of hormonal treatment of menopause and ageing.

Florence TREMOLIERES

Endocrinologist, MD.PHD, PU-PH in Medical Gynecology

Career path

Doctorate in Medicine in 1989, speciality Endocrinology and Metabolic Diseases. Post-doctoral training (1989-1991) in the Department of Bone Mineral Metabolism (Pr. D.J. Baylink), University of Loma Linda (California – USA). University thesis in Developmental Biology at the University Paul Sabatier (Toulouse III) in 1995. Habilitation to direct research (HDR) in 2002. She joined Team 9 (Dr. Françoise Lenfant, Pr. Pierre Gourdy) of the I2MC in 2006 as a clinician. Head of department since 2011 of the Menopause Centre, the only university centre in France dedicated to menopausal women. Founding member (2009) and President of the Study Group on Menopause and Hormonal Aging (GEMVi) (2019). Member of the boards of the European Menopause and Andropause Society (EMAS) (2009-2015) and of the International Menopause Society (IMS) (2014-2018). Officer of the Palmes Académiques (2017).

Area of expertise 

Study of the tissue consequences of estrogen deficiency states, particularly in terms of bone, cardiovascular and oncology in the post-menopause. Specialist in post-menopausal osteoporosis and metabolic bone pathologies.

She is a regular speaker at national and international congresses on the subjects of menopause and osteoporosis and is the author of more than 170 articles published in international or national referenced journals and of more than 15 book chapters.

Marie VALERA

Lecturer – Hospital practitioner

Career path

2005 : PhD in Dental Surgery. Paul Sabatier University (UPS) Toulouse III. 2005-2006: Master 2 Research. Mention Cellular and Integrated Physiology-Physiopathology.UPS Toulouse III. 2006-2009: University Doctorate in Cellular, Molecular and Integrated Physiopathology. INSERM U1048, I2MC. 2016 : Recruitment as Senior Lecturer/Hospital Practitioner.

Her current research focuses on understanding the pathophysiological mechanisms involved in the effects of estrogens on blood platelets and thrombosis in mouse models.

Area of expertise 
Haematology, animal experimentation, microsurgery

Mélissa BUSCATO

Engineer

Career path

Holder of a BTS BioAnalyses and Controls at the Saliège high school in Balma and an engineering degree in Sciences and Life of the Earth at the EPHE. She joined I2MC on a fixed-term contract in 2011.

She works as an engineer in the team on the study of vascular and metabolic effects of estrogens and SERMs.

Field of expertise 
Animal experimentation, cellular and molecular biology, histology.

Silveric GILARDI

Engineer

Career path

Holder of a Master’s degree in Biology-Health with a major in Physiopathology from the University Paul Sabatier, Toulouse, France after a university training in Toulouse.

He joined the team in September 2020 and works on the modulation of the oestrogen receptor in physiology and physiopathology, studying the effect of endocrine disruptors (ANSES funding).

Field of expertise 

Animal experimentation, cellular and molecular biology, histology, cytometry

Chanaëlle FEBRISSY

Post-Doc student (ANR and Ligue contre le cancer funding)

Career path

Master’s degree in Genes, Cells and Development obtained at Paul Sabatier University (UT3) in 2018. PhD student since November 2018.

Chanaëlle Fébrissy is a PhD student working on the identification of molecular and cellular mechanisms involving the estrogen receptor ERα during tumor angiogenesis.

Field of expertise 

Molecular and cellular biology, animal experimentation, imaging, cytometry.

Adrien GARGAROS

PhD Student at INSERM

Adrien Gargaros’ project focuses on the study of estrogen receptors in endometriosis lesions and the implementation of a new model for studying the pathology.

Career path

Master of Biology and Health specializing in Physiopathology at the University of Toulouse (2020). Study engineer since 2021.

Areas of expertise

Cell and molecular biology, Cell culture, Imaging, Animal experimentation, Estrogen receptor

Mariam RUSIDZE

Clinical Assistante 

Career path

Mariam Rusidze is an anatomo-pathologist who graduated from Tbilisi State Medical University in Georgia. She joined our team in 2018 as a Master2 Research student in Physiopathology from Paul Sabatier University. Currently a PhD student since October 2018, she is working on the physiology and pathophysiology of the estrogen receptor ERα in the reproductive system, fertility, as well as in endometriosis.

She received her M.D. in pathological anatomy- clinical pathology” – from Tbilisi State Medical University, Tbilisi (Georgia) and her Master degree in Physiopathology-from molecular to medical as an Erasmus student from Toulouse University III- Paul Sabatier, Toulouse in 2018. She recently obtained her Inter University Diploma (DIU) in Molecular Pathology at the University of Toulouse III-Paul Sabatier, Toulouse (2021).

Area of expertise

Human and murine histopathology diagnosis, animal experimentation, mouse ultrasound, imaging, molecular biology (RT-qPCR, RNAscope)