S. Dumas chair
Endothelial niche dynamics in Kidney Aging, disease and REpair (EndoKARE)
The endothelium is a dynamic and heterogeneous component of blood vessels that shapes tissue microenvironments. At the EndoKARE lab, we aim to identify drivers of renal endothelial niche dysfunction in kidney aging, injury and disease. Targeting the renal endothelium offers innovative opportunities to promote kidney repair and regeneration – an urgent need in our aging societies, with chronic kidney disease projected to be the fifth leading cause of death by 2050.
Team members
Sébastien DUMAS
Post-doctoral fellow
Engineer
Student
Endothelial metabolic determinants of glomerulosclerosis
Coordinator : Sébastien Dumas
Glomerulosclerosis is a common fibrotic lesion in chronic kidney disease (CKD) and kidney aging, contributing to glomerular dysfunction and progressive kidney function decline. Focusing on the glomerular endothelial niche, we deploy single-cell and spatial omics analysis along with state-of-the-art in vitro and in vivo models to characterize and target the molecular and metabolic dysfunction of glomerular endothelial cells and their niche in aging and CKD.
Selected publications
Endothelial to mesenchymal transition in kidney fibrosis Jacobs ME, de Vries DK, Engelse MA, Dumas SJ*, Rabelink TJ*. (*shared senior authorship) Nephrol Dial Transplant. 2024 Pubmed
Vasculogenesis in kidney organoids upon transplantation Koning M*, Dumas SJ*, Avramut MC, Koning RI, Meta E, Lievers E, Wiersma LE, Borri M, Liang X, Xie L, Liu P, Chen F, Lin L, Luo Y, Mulder J, Spijker HS, Jaffredo T, van den Berg BM, Carmeliet P, van den Berg CW, Rabelink TJ. (*shared junior authorship) NPJ Regen Med. 2022 Pubmed
Phenotypic diversity and metabolic specialization of renal endothelial cells Dumas SJ, Meta E, Borri M, Luo Y, Li X, Rabelink TJ, Carmeliet P. Nat Rev Nephrol. 2021 Pubmed
Single-Cell Transcriptome Atlas of Murine Endothelial Cells Kalucka J*, de Rooij LPMH*, Goveia J*, Rohlenova K, Dumas SJ, Meta E, Conchinha NV, Taverna F, Teuwen LA, Veys K, García-Caballero M, Khan S, Geldhof V, Sokol L, Chen R, Treps L, Borri M, de Zeeuw P, Dubois C, Karakach TK, Falkenberg KD, Parys M, Yin X, Vinckier S, Du Y, Fenton RA, Schoonjans L, Dewerchin M, Eelen G, Thienpont B, Lin L, Bolund L, Li X, Luo Y, Carmeliet P. Cell. 2020 (*shared junior authorship) Pubmed
Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation Dumas SJ, Meta E, Borri M, Goveia J, Rohlenova K, Conchinha NV, Falkenberg K, Teuwen LA, de Rooij L, Kalucka J, Chen R, Khan S, Taverna F, Lu W, Parys M, De Legher C, Vinckier S, Karakach TK, Schoonjans L, Lin L, Bolund L, Dewerchin M, Eelen G, Rabelink TJ, Li X, Luo Y, Carmeliet P. J Am Soc Nephrol. 2020 Pubmed
They are supporting our research
anr
Inserm/UPS UMR 1297 - I2MC Institut des Maladies Métaboliques et Cardiovasculaires
1 avenue Jean Poulhès - BP 84225 - 31432 Toulouse Cedex 4
Tél. : 05 61 32 56 00
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