Institute of Cardiovascular and Metabolic Diseases (I2MC - UMR1048)

The new Institute of Cardiovascular and Metabolic Diseases (I2MC) was created in Toulouse on January 1, 2011 by Inserm and Paul Sabatier University.

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More than 280 people (scientists, physicians, engineers, technicians, students, postdocs and administrators) are working at I2MC

The research activity focuses on metabolic, cardiovascular and renal diseases. The main feature of I2MC is the gathering of basic scientists together with clinicians working on metabolic risk factors (obesity, diabetes and dyslipidemia) and their cardiovascular complications (thrombosis, atherosclerosis, cardiac and renal failure).

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I2MC is composed of 14 research teams. The teams share a similar "research philosophy" consisting in multidisciplinary approaches from basic science to clinical trials. In terms of basic research, the laboratories have a large expertise in membrane and intracellular receptors, cell signaling, metabolic pathways, cell/cell interactions and the mechanisms of tissue remodeling. To establish the pathophysiological relevance of the results obtained in basic research, I2MC teams have created original animal models and phenotyping techniques that have gained national recognition and are one of the highlights of the Institute. Translation to the clinic is greatly facilitated by the location within the Rangueil site of Toulouse University Hospitals. Notably, clinical departments devoted to nutrition, cardiovascular and renal diseases, obesity and diabetes are in close vicinity of I2MC. It helps the involvement of a large number of MD-PhD to the scientific activity of the laboratories. More than 25 clinical research protocols coming from original research obtained by I2MC teams have been performed during the last three years.

The industrial valorization of the research is another strength of I2MC. Numerous structured collaborations are ongoing with industrial partners, from SMEs to big pharmas. I2MC research directly contributed to the creation of 4 start up companies.


 

 

Latest publications

Acute Bradykinin Receptor Blockade During Hemorrhagic Shock in Mice Prevents the Worsening Hypotensive Effect of Angiotensin-Converting Enzyme Inhibitor (team 12)

PMID : 26992065 | Revue : Crit Care Med

Auteurs : Charbonneau H, Buléon M, Minville V, Faguer S, Girolami JP, Bascands JL, Tack I, Mayeur N

Targeted resequencing identifies PTCH1 as a major contributor to ocular developmental anomalies and extends the SOX2 regulatory network. (team 12)

PMID : 26893459 | Revue : Genome Res.

Auteurs : Chassaing N, Davis EE, McKnight KL, Niederriter AR, Causse A, David V, Desmaison A, Lamarre S, Vi...

The use of urinary peptidomics in the assessment of suitability of mouse models for ageing (team 3)

PMID : 28199320 | Revue : Plos One

Auteurs : E. NKUIPOU-KENFACK, et al.

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