Bernard PAYRASTRE

Professor of Haematology/Haemostasis (PU-PH), Medical Faculty Toulouse Purpan.

Responsible of the Functional Unit of “Cardiovascular Haemostasis”, Laboratory of Haematology, University Hospital of Toulouse.

Short description of positions held or career path
Diplomas: HDR, PhD thesis, Medical Pedagogy, Specialized electron microscopy.
2001-08: Director of Research at CNRS, group leader at Inserm U563, Toulouse.
2008: Professor of Haematology/Haemostasis (PU-PH), Medical Faculty Toulouse Purpan.

Teaching
Pathophysiology of haemostasis (DFGSM2), research approach (PACES), conferences and training 3th cycle of medical studies (haematology), medical and scientific English (DCEM2 and 3), cell signalling mechanisms (M1 (Responsible of the M1), M2R, DIU).

Scientific activity and expertise
• Appointed member of Inserm Scientific Committee n°5 (2008-12) and scientific committees of: FRM (2012-16), La Ligue Nationale (2017-24), INTS (2014-19), ARC-CR5 (president 2011-14), FDF (2006-12), lipidomic platform of Toulouse (president since 2011), SAB of Cochin Institute (2016-23).
• Editorial board of Biochem J (2013-20), Adv Biol Reg (2011-), Leukemia (2007-10). Advisory Editorial Board of J Thromb Haemost (2008-21). Reviewer for Blood, Circulation Research, Haematological, JTH, TH, Nature Commun, BBA-lipids, etc. Evaluator of ANR, Welcome Trust, Italian Ministry of Research (PRIN), La Ligue Nationale, PHRC projects.
• Scientific committee « European Symposium on Hormones and Cell Regulation » (2005-), organizer of the 2009, 2014 and 2019 meetings. Co-organizer of the GEHT meeting (2002 and 2009), organizer of the 1st French-UK Platelet meeting (2009), founder and co-organizer of The Toulouse School of Lipids (since 2016).
• Mentor of 12 PhD thesis and 3 postdoctoral fellows, 8 of whom are independent investigators.
• Coordinator of research project (ANR project)
• Over 28 invited conferences abroad (FEBS, ETRO, ISTH, Keystone).

Awards
• CNRS Bronze medal 1998.
• Senior member of “Institut Universitaire de France (2014-19).
• Guillaumat Piel 2016 Price from « Fondation pour la Recherche Médicale ».
• FRM Team (2017-20 and 2022-25).

Sonia SEVERIN

INSERM researcher

Her current research focuses on the study of molecular and cellular mechanisms involving blood platelets and their precursors, megakaryocytes in different pathophysiological contexts.

Career path
Holds a Master’s degree in cell biology from Paul Sabatier Toulouse III (2002-06) and a MSC and PhD degrees in biology from l’Université Paul Sabatier Toulouse III University (2004-2007). After a postdoctoral experience in Birmingham (United-Kingdom) (2007-10), she joined B. Payrastre lab and got an Inserm permanent researcher position in 2013.

Main domains of expertise
Hemostasis, Thrombosis, Hematopoïesis, Cardiovasular and Metabolic Physiopathology, cell trafficking and signalling.

Marie-Pierre GRATACAP

INSERM researcher

Her current research focuses on the role of phosphoinositides on vascular integrity and the dialogue of the endothelium with platelets in different physiopathological contexts.

Career path
Master’s degree and PhD in Biology and Pharmacology of Hemostasis and Vessels at Paris VII (1996-1999). 2000-2003, Postdoc position at the Pharmacological Institute, University of Heidelberg, Germany). 2002-current INSERM researcher at the physiopathology centre of Toulouse and at the I2MC.

Main domains of expertise
Haemostasis and Thrombosis, Cardiovascular Physiology and Pathology, Actin cytoskeleton dynamics and phosphoinositide signaling.

Julien VIAUD

INSERM researcher

Julien Viaud is a cell biologist and a biochemist. His current research interests focus on the role of phosphoinositides and actin cytoskeleton dynamic in muscle cell differentiation and megakaryocyte interaction with extracellular matrices using genome engineered cell models.

Career path
Holds a Master’s degree in cell biology from Nantes University of and a MSC and PhD degrees in biology from Montpellier University (2007). After a postdoctoral experience in Philadelphia (2007-10), he joined B. Payrastre’s lab and got an Inserm permanent researcher position in 2016.

Main domains of expertise
Cell biology and biochemistry related to phosphoinositides signaling and actin cytoskeleton dynamic, genome editing.

Christophe COGNARD

Thibault LHERMUSIER

Agnès RIBES

University Lecturer – Hospital Practitioner (MCU-PH) in Haematology/Haemostasis, Toulouse III Faculty of Health, Medicine Department

As a medical biologist, my current work involves identifying abnormalities in platelet phenotyping from clinical consultations at the Centre de Référence des Pathologies Plaquettaires (CRPP), deciphering pathophysiological mechanisms, molecular characterisation of these abnormalities, and their possible modelling in vivo or in vitro in collaboration with the team.

I am also working on the identification of new markers specific to the megakaryocyte/platelet/extracellular vesicle axis that are relevant to the development of haematological (autoimmune, dysplastic, red cell) and extrahaematological pathologies, in collaboration with certain departments at Toulouse University Hospital.

Career path: Scientific career: Masters in Cellular and Molecular Biology (Toulouse 1996-98), DEA (Paris 1998-99), PhD in Science (Paris 1999-2002), Fellowship (Paris 2002-05). Private sector career (Toulouse 2005-07). Medical career: Externship (Toulouse 2008-13), Medical Biology Internship (Toulouse 2014-18), Gold Medal (Toulouse 2018-19), University Hospital Assistant (Toulouse 2019-22), MCU-PH since 2022.

Teaching: Toulouse Faculty of Health Medicine Department (DFGSM2, DFGSM3, DFASM2, DFASM3, ECOS), Paramedical Department (IPA), Francophone Inter-University Diploma in Haemostasis and Thrombosis (Biology and Haemostasis module), forthcoming M1 course (intracellular calcium).

Areas of expertise: Clinical, on constitutional or acquired haemostasis diseases (haemorrhagic and thrombotic components), their biological investigations and medical management. Scientific, on investigations into the megakaryocyte/platelet/extracellular vesicle axis and intracellular calcium.

Sophie VOISIN

Fanny VARDON-BOUNES

Gaëtan CHICANNE

Research engineer INSERM

He is a lipid biochemistry and molecular biology engineer. As part of the team’s research themes, his activities focus on development of new techniques to quantify phosphosinositides base on mass spectrometry and design news tools in molecular biology.

Career path
He holds a Master’s degree in biochemistry and a MSC in molecular biology from Paul Sabatier University – Toulouse. After a first experience at Bayer Cropscience in Lyon, he moved to B. Payrastre’s lab in 2003 and got an INSERM permanent engineer position in 2006.

Main domains of expertise
Lipid biochemistry (phosphoinositides quantification). Cellular and molecular biology (cloning, genome editing). Lentivirus production.

Cédric GARCIA

Hospital Engineer / PhD Student (funded by CHU Toulouse)

Since 2006, I have been responsible for the study of rare thrombopathies and technological development in the hospital laboratory for platelet pathophysiology in clinical research. I began my PhD in September 2021 within Professor Payrastre’s team. My thesis focuses on platelet interactions with pathogens (viruses, bacteria), particularly their role in innate immunity and the inflammasome.

Career Path

Laboratory Technician at the Reference Center for Platelet Disorders, Hematology Laboratory, CHU Purpan/Rangueil in Toulouse from 2006 to 2017. After obtaining my engineering degree from EICNAM, I was appointed as an engineer in the hematology laboratory in 2017. 2015: Engineering degree in Life Sciences, Biological Engineering option, EICNAM, Toulouse. 2005: Professional license in Asset and Personnel Safety, HSE option in the health sector, Faculty of Pharmacy, Toulouse. 2004: B.T.S. in Biological Analysis, Jolimont High School, Toulouse.

Areas of Expertise

Platelet biology and signaling, cytometry, imaging.

Jean-Marie Xuereb

Engineer University

He has expertise in hemostasis and Hematopoïesis. As part of the team’s research themes, his activities focus on exploring platelet homeostasis and function in related human diseases.

Career path
Master in Biotechnology and PHD in Biology in Toulouse in 1998, post-doctorate in R&D in private companies, recruited as IE2 university (2004-2008), attached to I2MC (2008-2012), finally IE2 then IEHC since 2018 in the team of B. Payrastre.

Main domains of expertise
Cellular and molecular biology, biochemistry, cytometry, imaging.

Anne MAZARS

Research Engineer

Career path
Anne received her PhD in Cancerology at University of Paris V followed by postdoctoral trainings in private companies and public laboratory. She joined our team in 2023 as an engineer to participate to the “newpi” project.

Main domain of expertise
Imaging, protein-protein interaction, cellular & molecular biology

Laura BOUVET

PhD Student

Oportune KPOTOR

PhD Student

Juline ARDANUY

Christophe FERREIRA

Mathilde MIQUEL

Ingineer assistant

Project: Roles of OMV HlyF in platelet function modulation and consequences for hemolytic uremic syndrome.

Career: Master’s degree in Biology-Health, Digestive Health and Nutrition in 2023.

Areas of expertise: Histology, metabolism, pathophysiology, animal experimentation

Nadège PREUILH