team A. Bouloumié 

Anne BOULOUMIE-DIEHL

PhD, HDR, INSERM Research Director (DR2), Team Leader

Career path
PhD in pharmacology, director M. Lafontan, Université P Sabatier, Toulouse (1994); Post-doc, Cardiovascular Institute (R. Busse), Frankfurt, Germany (1994-1998); CRCN INSERM U598 (1998-2001); Kovalevskaja award, Frankfurt, Germany (2002-2006); AVENIR award, I2MR, Toulouse (2007-2011), Since 2012, INSERM team leader, I2MC.

Main domains of expertise  
Adipose tissue, progenitor, immune cells, endothelial cells, adipogenesis, inflammation, fibrosis, senescence, aging, obesity.

Anaïs BRIOT

PhD, Inserm Researcher

Career path
PhD in Molecular, Cellular and Integrated Pathophysiology, supervisor A Hovnanian (2009); Post-Doc Laboratory of L. Iruela-Arispe, UCLA, USA (2010-2015); Since 2016, CRCN INSERM Team Bouloumié, I2MC, Toulouse.

Main domains of expertise  
Vascular biology, cell biology, endothelial cells, adipose tissue, inflammation, aging, senescence.

Xavier COLLET

PhD, HDR, Research Director INSERM 

Career path
PhD in Biochemistry (1988), Post-Doc in the laboratory of C. Fielding (1988-1991), Sabbatical stay: Columbia University, Department of Medicine, New-York, (A. Tall).  Since 2021, DR INSERM in Bouloumié team, I2MC, Toulouse. Director of CREFRE (July 2020), Director of SFR-BMT (since 2011), Co-director of Génotoul (since 2011).

Main domains of expertise  
Lipoprotein metabolism, lipids, cholesterol, intestinal absorption of lipids, microbiota.

Audrey FERRAND

PhD, Inserm Researcher

Career path: Doctorat en pharmacologie, directeurs L. Pradayrol & C. Seva, Université P. Sabatier, Toulouse (2000-2004) ; Visiting scientist, T.C. Wang Lab, University of Massachussetts, Worcester, USA (2002 & 2003) ; Post-doc, J. Settleman Lab, MGH Cancer Center-Harvard Medical School, Boston, USA (2005-2006) ; Biomedical scientist, G. Baldwin & A. Shulkes Lab, University of Melbourne, Melbourne, Australia (2006-2009) ; CR1 INSERM (2009) ; HDR (2017); Responsable d’équipe INSERM, IRSD (2021-2025) ; Co-fondatrice du GDR Organoïdes (2021) ; Présidente du Conseil Scientifique du FC3R (2022-présent) ; Membre du comité exécutif du PEPR MED-OOC (2024-présent), Pilote du Réseau Thématique Organoïdes national (2025-présent).

Since October 2025, Audrey and her group (Muriel Quaranta-Nicaise, Duvan Rojas-Garcia, Alexis Arcas, Rémi Centrès, and Théo Calderon) have joined the Dinamix team. Within the I2MC, Audrey created and co-leads the NAMs research axis.

Area of expertise : Intestinal pathophysiology, Intestinal epithelium, Stem cells, Microenvironment, Fibroblasts, Extracellular matrix, Fibrosis, Tumor initiation, Organoids, Organ-on-a-chip, Mechanobiology.

Florence TATIN

Researcher (CRCN INSERM)

Florence Tatin received her PhD in cell biology from University of Bordeaux in 2006. She did a post-doc in the fields of lymphatic development in the lab of Taija Makinen in London and then joined I2MC in September 2014 to work on the role of lymphatic vessels in cardiovascular diseases in the lab of Anne-Catherine Prats and Barbara Garmy-Susini. She obtained her position CRCN in 2018. Her research project now focusses on the importance of lymphatic endothelium in metabolic diseases, obesities and diabetes.

Main domains of expertise
Vascular development, valvulopathy, cell adhesion and signalisation.

Pauline DECAUNES BESSEDE

Engineer INSERM

Career path
Licence professionnelle de Biotechnologies, Université Versailles- St Quentin en Yvelines, (2004); Assistant Engineer, INRA Jouy-en-Josas (2004-2006), INSERM Equipe AVENIR/Bouloumié, I2MR, Toulouse (2006-2009); TCN INSERM Equipe Bouloumié, I2MC, Toulouse (2010-2019); Since 2019, AI INSERM Team Bouloumié, I2MC.

Main area of expertise
Isolation and culture of human and mouse vascular and stromal cells by flow cytometry and/or magnetic beads; Approaches: Imaging, transcriptional, protein and lipid analyses.

Léopold Devineaux

Muriel QUARANTA-NICAISE

Engineer 

Career path: Muriel obtained a Master’s degree in Cell Biology and Physiology from Paul Sabatier University, Toulouse, in 1996. From 1999 to 2013, as a Research Assistant, she worked at the Laboratory of Cell and Molecular Biology and Proliferation Control (B. Ducommun’team, Paul Sabatier University, Toulouse). She then passed the competitive examination for engineering positions and, from 2013 to 2024, joined the Toulouse Center for Physiopathology (N. Vergnolle’team) and the Institute for Research in Digestive Health. (A. Ferrand’ team).  She joined the I2MC in 2024.

Domaine d’expertise :Muriel specializes in the setup and culture of organoids. She participates in team projects and develops new techniques and approaches in cell biology and imaging. Approaches: imaging, protein analysis, and cell culture.

Juline MARJOLLET

PhD Student  

Le projet de thèse de Juline consiste à étudier les effets des œstrogènes sur les cellules endothéliales du tissus adipeux (thèse en cotutelle avec l’équipe Dinamix).

Cheminement de carrière

Ecole d’ingénieur Polytech Marseille en génie biologique spécialité biotechnologies & Master de recherche spécialité maladies métaboliques et vasculaires.

Domaines d’expertise

Tissu adipeux, aorte, cellules endothéliales, œstrogènes, approches in vivo.

Alexis ARCAS

PhD Student  

Alexis’s PhD project focuses on the development of synthetic extracellular matrix (ECM) models using multiphoton polymerization, a high-resolution 3D printing technique (Nanoscribe). We print submicrometer fiber networks with a stiffness similar to collagen, made of acrylic materials. The dimensions, position, orientation, density, and organization of the network are precisely controlled to determine the microarchitecture and mechanical properties of the matrices. This approach will allow us to better characterize the phenotype of human colon fibroblasts in artificial matrices mimicking the ECM of a healthy colon or one affected by Crohn’s disease. PhD co-supervised with LAAS-CNRS, ELiA team (2024-present).

Career path: Bachelor’s degree in Cell Biology and Physiology (BCP), University of Toulouse (2019-2022); Master’s degree in Biology and Health, specializing in Therapeutic Innovations and Tissue Engineering (IT²), University of Toulouse (2022-2024).

Area of expertise: Intestinal epithelium, Microenvironment, Fibroblasts, Extracellular matrix, Fibrosis, Organs-on-a-chip, Two-photon polymerization.

Anne Gosset

PhD Student

Duvan ROJAS-GARCIA

PhD Student  

Duvan’s doctoral project involves developing a platform for therapeutic screening of intestinal diseases using a colon-on-a-chip with a controlled environment. His scientific work focuses on 3D cell culture and microfluidics. (Thesis partly carried out within the framework of the ENVie project of the PEPR MED-OOC, co-supervised with the LAAS-CNRS, ELiA team).

Career path: Bachelor of Engineering in Chemistry, National University of Colombia, Bogotá (2016-2022); Master of Engineering degree in Biotechnology, AgroParisTech, Paris (2020-2022); PhD in Biotechnology, supervised by A. Ferrand & L. Malaquin, University of Toulouse, Toulouse (October 2022-June 2026).

Areas of expertise: Organ-on-a-chip, extracellular matrix, 3D culture, intestinal epithelium, bioprocesses

Théo CALDERON

PhD Student  

Théo’s PhD project involves optimizing and utilizing a colon-on-a-chip model developed in the laboratory in collaboration with LAAS-CNRS. This model, seeded with colorectal organoids and primary fibroblast cultures derived from patients, will allow researchers to study epithelial regeneration, better understand the intestinal alterations present in the context of inflammatory bowel diseases and metabolic diseases, particularly obesity and metabolic syndrome, and identify new therapeutic strategies. (PhD carried out within the framework of the ENVie project of the PEPR MED-OOC, co-supervised by LAAS-CNRS, ELiA team, 2025-present).

Career path:Bachelor’s degree in Biology (2023), University of Bordeaux. Master’s degree in Health Biology, specializing in Cell Biology, Physiology and Pathology (2025), University of Bordeaux.

Area of expertise: Cell biology, biotechnology, pathophysiology, intestinal epithelium, stem cells, microenvironment, organoids, organs-on-a-chip.

Rémi CENTRES

PhD Student  

Rémi’s PhD project involves developing a porcine colon-on-a-chip model to study alternatives to antibiotics. (PhD co-supervised with GenPhySE, MUSE team, INRAE).

Career path: Master’s degree in Biology-Health, specializing in Therapeutic Innovations and Tissue Engineering, at Paul Sabatier University in Toulouse (2025).

Area of expertise: Organoids, Organ-on-a-chip, Porcine intestinal physiology, Intestinal epithelium, Stem cells, Microenvironment.