Team C. MORO / D. LANGIN

Cédric MORO

Research director (INSERM)

Cedric Moro received a PhD in 2005 and Habilitation in 2012 in Pathophysiology from Paul Sabatier University, Toulouse, France. He is currently Research Director at Inserm and head of Team MetaDiab at I2MC, Inserm/Paul Sabatier University UMR1297.

Career path
After a 3-year post-doctoral fellowship at the Pennington Biomedical Research Center (Baton Rouge, USA), he was appointed Research Investigator at Inserm in 2008. He was the recipient of the Young Investigator Award of EASO in 2004 and the Auguste Loubatières Award of SFD in 2020.

Main domains of expertise
Physiopathology ; Metabolism ; Nutrition ; Exercise ; Obesity ; Type 2 Diabetes

Dominique LANGIN

Team leader/I2MC director

Dominique Langin, DVM PhD, is Professor at Toulouse University Hospitals and a member of Institut Universitaire de France. He is studying metabolism in the context of obesity and diabetes and has led research teams and unit in that field.

Main domains of expertise
Obesity, diabetes, metabolism, adipose tissue

Virginie BOURLIER

Pierre-Damien DENECHAUD

INSERM researcher

Isabelle HARANT

Dominique LARROUY

Claire LAURENS

Associate Profesor

Claire Laurens’ projects focus on understanding the inter-organ communication between skeletal muscle and other metabolic organs in response to exercise. She is also interested in the metabolic and anabolic disorders induced by physical inactivity and aging at both muscle and whole-body levels.

Main domains of expertise
Skeletal muscle, lipids, metabolic flexibility, energy metabolism, inter-organ crosstalk, exercise, physical inactivity, translational research.

Etienne MOUISEL

Associate Profesor

Career path
2007: PhD degree – Exercise physiology & neuromuscular diseases. 2007-2011 : Postdoctoral fellow – Skeletal muscle physiopathology. Since 2011: Assistant/Associate Professor – Animal physiology / Lab: adipose metabolism, lipolysis, metabolic organs cross-talk, diabetes, obesity.

Main domains of expertise
Physiology, animal experiments, adipose tissues, skeletal muscle

Geneviève TAVERNIER

CNRS researcher

Career path
PhD in Human Physiopathology from Paul Sabatier University in 1996, Toulouse, France. Post-doctoral internship from February 1996 to August 1998 at the Institut Cochin de Génétique Moléculaire, Paris, France. Recruited at the CNRS in 1998 and has been working in the same laboratory since then, successively named Laboratory of Research on Obesity and MetaDiab. Mainly in charge of the creation of new animal models by additive transgenesis and thanks to the CRISPR/Cas9 system.  In charge of part of their phenotypic characterisation using in vivo, ex vivo and in vitro approaches.
Deputy director of the Inserm unit UMS006 from 2011 to 2015 and head of the transgenesis service of this unit from 2011 to 2020.

Main domains of expertise
Transgenesis and animal manipulation, metabolism, adipose tissues, inter-organ dialogues.

Nathalie VIGUERIE

Researcher

Multiomics in clinic to discover new genes and pathways involved in the pathogenicity of obesity. Scientific coordinator of I2MC Bioinformatics Core Facility. Member of the PHASE Research Division of INRAE. Coordination of JPI HDHL miRDiet project and Genomics Research Line of FP6 DiOGenes Diet, Obesity and Genes project. Teaching activities with functional genomics sessions in Masters

Main domains of expertise
Obesity, adipokines, biomarkers, -omics, network analyses, missing data imputation

Eric BIETH

Sylvie CASPAR-BAUGUIL

PharmD-PhD

Doctor in Pharmacy, she received her Ph.D degree in Immunology in 1993 and Habilitation (HDR) in Pathophysiology in 2008 from the Paul Sabatier University, Toulouse, France. She joined our team in January 2010 in the field of metabolic disorders associated with obesity

Main domains of expertise
Biochemistry, fatty acid metabolism, lipid analyses, nutrition

Isabelle DE GLISEZINSKI

Emilie MONTASTIER

MD-PhD

Emilie Montastier is an associate professor in Endocrinology Diabetology Metabolic Diseases and Nutrition at the Paul Sabatier University, Toulouse, France. She is an endocrinologist at the Toulouse University Hospital. She defended her PhD Thesis in the lab in 2014 with a topic about obese patients adipose tissue omics to understand the adaptive mechanisms after a weight loss. She is involved in many clinical studies.

Claire THALAMAS

Elena GRISETI

Laura BOTTIN

Camille FOURNES

Laurie FRANCES

university hospital assistant

Career path
Laurie Frances completed Pharmacy studies and received a Master degree in Physiology from the Paul Sabatier University, Toulouse, France, in 2020. She started a PharmD and a PhD in our team in October 2020, both in the field of adipose tissue secretions at the MetaDiab lab, INSERM U1297.

Main domains of expertise
Biochemistry, Cellular Biology, Pharmacology

Marlène LAC

PhD Student

I obtained a Master’s degree in Digestive Health and Nutrition at the Paul Sabatier University of Toulouse in 2021. I joined the team in January 2021 for a M2 internship and I am pursuing since October 2021 with a PhD, which aims to determine the key role of the ANP/GCA system in the control of brown adipose tissue functions. As well as to characterize new target genes of this pathway which could allow to identify new targets in the prevention or treatment of type 2 diabetes.

Benjamin LAIR

Post doctoral fellow

Benjamin Lair graduated from the Ecole supérieure de biotechnologies de Strasbourg in 2017. He joined the team in 2019 when he was enrolled in the sport performance optimization master program at the Paul Sabatier University in Toulouse. His PhD work aims to understand the impact of sphingolipids on muscle metabolism.

François-Xavier PATARCA

Camille BERGOGLIO

Engineer

Career path
Camille Bergoglio received her Master degree in Health Biology option Pathophysiology from the Paul Sabatier University, Toulouse, France, in 2019. She joined our team in October 2019 as an engineer in the field of pathophysiology of metabolic disorders and diabesity at the MetaDiab Lab, INSERM U1297, I2MC.

Main domains of expertise
Cellular & Molecular Biology, metabolic flux studies and biochemistry

Stéphanie CASSANT-SOURDY

Technician

A graduate in animal testing at the Toulouse Veterinary School in 2006, she joined our team in November 2020 on Obesity and Type II Diabetes, INSERM U1297. Stephanie began her career at the CRCT: surgery and imaging of small animals applied to pancreatic carcinogenesis.

Marie-Adeline MARQUES

Engineer Assistant

Holder of a BTS “Biological Analysis”, I joined INSERM in January 1992 in Marseille. From 1994 to 2004, I worked at the Toulouse Clinical Investigation Center as a clinical research technician. In 2004, I joined the I2MC where I still carry out my duties

Main domains of expertise
Clinical research, dosages and cellular biologie, histology and imaging

Laurent MONBRUN

Assistant engineer

Laurent Monbrun received his two-years technical degree in Biochemist option biochemistry and biological engineering from the Saliège Private high school, Toulouse, France, in 1999. He joined our team in february 2007 as an assistant engineer in the field of metabolic disease at the Metadiab, INSERM U1297.

Career path
Six years in a laboratory whose specialities were molecular and cellular biology. Two years to set up a technical platform specializing in mices assays. Engineer assistant in MetaDiab laboratory since 2007 ; my function is the genotyping/phenotyping of different murine lines.

Main domains of expertise
Animal experiments, genotyping and management of murines colonies, Analysis of nucleic acids by PCR or qPCR, Analysis of protein by western-blot, biochemical and cytotkines assays, cellular & molecular biology. ISO 9001:2015 et NFX 50-900:2016 accreditation in the Phenotyping Service.

Alexandra MONTAGNER

INSERM researcher

Career path
After her PhD in Cellular Signaling (2006), Alexandra joined Pr Walter Wahli’s lab in Lausanne at the CIG (Center for Integrative Genomics) where she studied PPARb/d molecular function in skin carcinoma. In 2011, she then worked as a post-doc in Dr Hervé Guillou’s lab (INRA/ToxAlim, Toulouse) where she investigated PPARs specific function in hepatocytes during Non-Alcoholic Fatty Liver Diseases development (NAFLD). Since 2016, her research aims to decipher the impact of estrogens on the sexual dimorphism described in hepatic physiological functions and Non-Alcoholic Fatty Liver Diseases (NAFLD) progression together with Pr Pierre Gourdy.

Main domain of expertise
Nuclear Receptors, Liver, non-alcoholic fatty liver diseases (NAFLD), Estrogens.

Pierre GOURDY

Professor in Endocrinology, Diabetes & Metabolic Diseases

Career path

Graduated in 1997 (MD) and 2004 (PhD), Pierre Gourdy was promoted in 2005 to Professor in Endocrinology, Diabetes and Metabolic Diseases at Toulouse 3 University and Toulouse University Hospital. Since 2016, he leads the University Federation IMPACT (Innovative Medicine for the Prevention and treatment of Cardiovascular and metabolic diseases) which federates 10 clinical teams and 4 research institutes to promote research efforts in the field of metabolic and cardiovascular diseases.

Main domains of expertise

Diabetes, non-alcoholic fatty liver diseases (NAFLD). Sex steroids, nuclear receptors, translational research