Team C. MORO / D. LANGIN

MetaDiab – Pathophysiology of Metabolic Disorders and Diabesity
The team MetaDiab uses a highly translational medicine approach of the study of metabolism combining innovative cell and mouse models to decipher molecular mechanisms of metabolic disorders, and clinical studies in nutrition and exercise with deep phenotypic investigation. The team aims at understanding the biological determinants and molecular mechanisms of metabolic disorders in various pathophysiological contexts (obesity, aging, type 2 diabetes, physical inactivity). Using a highly integrative bedside-to-bench approach, we investigate novel targets and mechanisms in cell and mouse models as well as in humans. Our projects are focused on the underlying mechanisms of insulin resistance, lipid droplet and metabolic dysfunction in skeletal muscle and adipose tissue, as well as their crosstalk in metabolic regulation and diseases
TEAM MEMBERS

Cédric MORO

Dominique LANGIN

Virginie BOURLIER

Pierre-Damien DENECHAUD

Isabelle HARANT

Dominique LARROUY

Claire LAURENS

Etienne MOUISEL

Geneviève TAVERNIER

Nathalie VIGUERIE

Eric BIETH

Sylvie CASPAR-BAUGUIL

Isabelle DE GLISEZINSKI

Emilie MONTASTIER

Claire THALAMAS

Elena GRISETI

Laura BOTTIN

Camille FOURNES

Laurie FRANCES

Marlène LAC

Benjamin LAIR

François-Xavier PATARCA

Camille BERGOGLIO

Stéphanie CASSANT-SOURDY

Marie-Adeline MARQUES

Laurent MONBRUN

Alexandra MONTAGNER

Pierre GOURDY
Lipotoxicity and muscle dysfunction

Coordinators : Virginie BOURLIER, Cédric MORO
Obesity, type 2 diabetes, aging and sedentarity are associated with defective lipid metabolism, adipose tissue dysfunction and ectopic lipid deposition in skeletal muscle. We study the role of inter/intra-muscular and intramyocellular lipid droplets dynamics as triggers of metabolic and functional impairments in skeletal muscle.
Adipocyte lipid droplet dysfunction
Coordinators : Pierre-Damien DENECHAUD, Etienne MOUISEL, Geneviève TAVERNIER, Dominique LANGIN.
Adipocyte lipid droplet is the main store of energy in the body. Lipid droplet proteins, especially those involved in fat mobilization, influence the metabolism of adipocytes. Adipocyte metabolism is strongly associated with the metabolic disorders observed during obesity. We are studying, in particular, the impact on the liver. These questions are being studied within the framework of the ERC Synergy SPHERES project (link to https://erc-spheres.univ-tlse3.fr/) and other research programs.
Metabolic organ crosstalk

Coordinators : Nathalie VIGUERIE, Sylvie CASPAR-BAUGUIL, Geneviève TAVERNIER, Claire LAURENS, Cédric MORO
The overarching goal of this research program is to elucidate the dynamic interplay between skeletal muscle, adipose tissue and other organs (liver, pancreas) critical for the maintenance of glucose homeostasis and the development of Type 2 Diabetes. DIABKINE project (Occitanie Region/FEDER R&S 2019 – MP0021755 funds): Role of novel exerkines in prevention of metabolic diseases. In this project, we have identified novel exerkines, produced by skeletal muscle contraction, able to mediate some of the beneficial effects of exercice in health via auto-paracrine and endocrine routes such as GDF15 (Laurens et al. JCI Insight 2020).
Translational metabolic research

Coordinators : Emilie MONTASTIER, Claire THALAMAS, Claire LAURENS, Dominique LARROUY, Isabelle DE GLISEZINSKI, Isabelle HARANT, Nathalie VIGUERIE, Cédric MORO
- Identify adipose- and muscle-derived circulating biomarkers of type 2 diabetes development and remission after bariatric surgery
- Impact of artificial gravity and exercise as countermeasures to prevent simulated microgravity-induced muscle atrophy and metabolic inflexibility
publications
Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis. Carper D, Coué M, Nascimento EBM, Barquissau V, Lagarde D, Pestourie C, Laurens C, Petit JV, Soty M, Monbrun L, Marques MA, Jeanson Y, Sainte-Marie Y, Mairal A, Déjean S, Tavernier G, Viguerie N, Bourlier V, Lezoualc’h F, Carrière A, Saris WHM, Astrup A, Casteilla L, Mithieux G, van Marken Lichtenbelt W, Langin D, Schrauwen P, Moro C. Cell Rep. 2020. Pubmed
Reappraisal of the optimal fasting time for insulin tolerance tests in mice. Mol Metab. 2020. Pubmed
Growth and differentiation factor 15 is secreted by skeletal muscle during exercise and promotes lipolysis in humans. JCI Insight. 2020.Pubmed
Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity.
Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity. Barquissau V, Léger B, Beuzelin D, Martins F, Amri EZ, Pisani DF, Saris WHM, Astrup A, Maoret JJ, Iacovoni J, Déjean S, Moro C, Viguerie N, Langin D. Cell Rep. 2018. Pubmed
FUNDINGS
Equipe Cedric Moro/Dominique Langin

















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