Membres de l'équipe

LANGIN
Dominique
(PU-PH)

LANGIN Dominique (PU-PH)

dominique.langin@inserm.fr

05 61 32 56 28

LANGIN Dominique
Born: 13th december 1962
E-mail address: dominique.langin@inserm.fr

University degrees
1993 Capacity to Direct Research Programs, Paul Sabatier University, Toulouse
1990 Doctor of Science (Ph.D.), Paul Sabatier University, Toulouse. With honors
1988 Doctor in Veterinary Medicine (D.V.M.) National Veterinary School of Nantes. Faculty of Medicine, Nantes. With honors.
1987 Diploma for Advanced Level Studies (M2R). University of Rennes. National Agronomic School of Rennes. Ranked first
1986 Certificate of Veterinary Medicine Practice

Scientific career
2011- Deputy Director of the Institute of Metabolic and Cardiovascular Diseases, Inserm-Paul Sabatier University. Head of the Obesity Research Laboratory
2006- Professor of Nutrition and Medical Biochemistry, Purpan Faculty of Medicine
2003- Co-director with Prof. Vladimir Stich of the Franco-Czech Laboratory for Clinical Research on Obesity
2006-2010 Head of the Obesity Research Laboratory at the Institute of Metabolic and Cardiovascular Diseases
2003-2006 Director of the Obesity Research Unit, Inserm-Paul Sabatier University
2000-2006 Director of Research at Inserm (National Institute of Health and Medical Research)
1993-2000 Established Investigator at CNRS (National Center for Scientific Research)
1990-1993 Visiting Scientist of the Swedish Medical Research Council; Research Associate in Molecular Endocrinology, Faculty of Medicine, Lund University
1987-1990 Research Assistant, INRA (National Institute of Agronomic Research)
1986-1987 Assistant, Department of Nutrition, National Veterinary School of Nantes

Hospital duties (current)
Head of the Molecular Genetics Laboratory and Nutritional Biochemistry and Department of Clinical Biochemistry, Toulouse University Hospitals
Hold Agreement for Genetic Testing of Mature Onset Diabetes of the Young (MODY)

Teaching and Training
Training of 12 PhD students and 18 MSc (1-year research projects) students
Responsible of human genome and molecular biology courses, courses in biochemistry and medical research (first year of medical studies common to medicine, pharmacy and dentistry)
Responsible for Nutrition courses (second and third year of medical studies)
Post-graduate courses at Toulouse University Hospitals in Nutrition, Clinical Biochemistry and Metabolic Diseases

Scientific activities and expertise (current)
Evaluation Committees at the Karolinska Institute
International, European and French Associations for the Study of Obesity
French-speaking Diabetes Society
Expert for Nature, Nature Medicine, PNAS, PLoS biology, Genes & Development, Cell Metabolism,…
218 original publications and 70 review articles & book chapters. SIGAPS 1995-2016 : 3535.
11900 citations, h-index 58.

Distinctions
2014 Appointment as member of the Institut Universitaire de France
2011 Friedrich Wassermann Life Time Achievement Award of the European Association for the Study of Obesity
2009 Laboratory award from the Fondation pour la Recherche Médicale
1998 Andre Mayer Award of the International Association for the Study of Obesity
1996 Young Investigator Award of the European Association for the Study of Obesity
MORO
Cédric
(CR)

MORO Cédric (CR)

cedric.moro@inserm.fr

05 61 32 56 26

Cedric MORO, Ph.D.
Born on September 26, 1978

Education

2012 Habilitation (HDR), Pathophysiology, University of Toulouse, France
2005 Ph.D., Physiology, University of Toulouse, France
2002 M.S., Integrative Physiology, University of Lyon, France
2000 B.S., Cellular Biology and Physiology, University of Toulouse, France

Scientific Career

2016-present Co-director of the Obesity Research Laboratory, INSERM UMR 1048, Toulouse, France

2013-present Principal Investigator 1st class, INSERM UMR 1048, Toulouse, France

2009-2013 Principal Investigator 2nd class, INSERM UMR 1048, Toulouse, France

2007-2009 Instructor Research, John McIllheny Skeletal muscle Physiology Laboratory,
Pennington Biomedical Research Center, Baton Rouge, USA

2006-2007 Post-Doctoral Fellow (Mentor: Steven R. Smith, M.D, Professor)
Pennington Biomedical Research Center, Molecular and Experimental Endocrinology Laboratory, Baton Rouge, Louisiana, USA

2005-2006 Post-Doctoral Fellow (Mentor: Dominique Langin, D.V.M, Ph.D, Professor)
Obesity Research Unit, National Institute of Health and Medical Research (INSERM) U586, Toulouse, France; and Franco-Czech laboratory for clinical research on obesity, Prague, Czech Republic.

Training and expertise

Supervisor of 3 PhD students and >10 Master students.

70 original articles, 11 reviews, 3 book chapters

Reviewer for several funding agencies (Diabetes UK, IDEX and CORDDIM Ile de France, AFM-Téléthon, ANRT, FWF, Fond Suisse, ERC, Deutch Diabetes Foundation, Croatian Science Foundation, Fond Belge...) and Journals (Mol Metab, Cell Reports, Diabetes...).

Awards

2008 Ethan Sims Young Investigator Award Finalist (The Obesity Society)
2007 “Rose Lamarca” Award for Clinical Research, (Fondation pour la Recherche
Médicale)
2007 Young Investigator Award of the European Association for the Study of Obesity
2006 Post-doctoral Fellowship Lavoisier, Egide foundation
2004 Award of the French Association of Physiologists
TAVERNIER
Geneviève
(CR)

TAVERNIER Geneviève (CR)

genevieve.tavernier@inserm.fr

05 61 32 56 26

Geneviève TAVERNIER, Ph.D.

Education

1996 Ph.D, Physiopathology, Paul Sabatier University, Toulouse, France
1991 M.S., Human Physiopathology, Paul Sabatier University, Toulouse, France

Scientific Career

1998-present : scientific investigator from CNRS at the National Institute of Health and Medical Research, UMR1048 Inserm/Paul Sabatier University, Toulouse, France
1996 to 1998 : postdoctoral fellow at the Cochin Institute for Molecular Genetics (Mentors Dominique Daegelen and Jean-Paul Concordet), Paris, France
2011-2016 : deputy director of the UMS006/CREFRE Inserm/Paul Sabatier University, Toulouse, France
2011-present : head of the transgenic core facility of the UMS006/CREFRE Inserm/Paul Sabatier University, Toulouse, France

Training, expertise and membership

Co-instructor of 4 PhD students and of around 10 master students.
1999-present : teaching in Master of Research and Professional Master at the Paul Sabatier University, Toulouse, France
42 original scientific articles
Reviewer for scientific journals

2008-present : Life Science et European Journal of Endocrinology.
2016 : Journal of Genetics and Genomics
2007-2016 : ROCAD french network, work package nb8 “New technical approaches in transgenesis”
2012-2016 : ROCAD french network, work package nb10 “Resources and developments in mutagenesis and transgenesis”
2013-2016 : Celphedia Research Infrastructure (la Création l’ELevage le PHEnotypage la DIstribution l’Archivage), workpackage « Mutagenesis to create, validate and improve new technical tools such as TaleN and CrispR)
2016-present : member of the Celphedia/Réseau network, 2 work packages : “genetic engineering” and “ES cells and microinjection”
2014-present : member of the local ethical committee for animal experimentation nb CEEA122 of the UMS006/Crefre. Member of the scientific council of the VibioSphen biotech.
VIGUERIE
Nathalie
(CR)

VIGUERIE Nathalie (CR)

nathalie.viguerie@inserm.fr

05 61 32 56 31

BOURLIER
Virginie
(MCF)

BOURLIER Virginie (MCF)

virginie.bourlier@inserm.fr

05 61 32 56 26

Virginie BOURLIER, Ph.D.
Born on March 30, 1972

Education
1999 Ph.D, Biology, Joseph Fourier University, Grenoble, France
1995 M.S., Cellular and Molecular Biology, Joseph Fourier University, Grenoble, France
1993 B.S., Cellular Biology and Physiology, Joseph Fourier University, Grenoble, France

Scientific Career
2001-… Associate professor, UMR 1048 INSERM/Paul Sabatier University, Toulouse, France
1999-2001 Post-Doctoral Fellow/Research Associate (Mentor: Dr. Walter Boyle, M.D, Professor), Washington University School of Medecine, Department of Anesthesiology, St Louis, MO, USA.

Training, expertise and membership
Supervisor of 2 PhD students and >10 Master students.
29 original scientific articles.
Reviewer for scientific journals (PLoS One, Stem Cells Int, Int. J Obes, J Clin Endocrinol Metab...).
Member of the French society of study and research on obesity (AFERO) and the French-speaking society of diabetes (SFD/ALFEDIAM)
Reviewer for research proposal calls of the Federal Toulouse University Midi-Pyrénées (COMUE, 2014-2016).
Member of academic council of Paul Sabatier University (2011-2015), Toulouse, France.

Awards/Fundings
2007, Paul Sabatier University bonus quality research (BQR) allocation
2009, ALFEDIAM / Roche Diagnostic allocation
2013, Paul Sabatier University bonus quality research (BQR) allocation
HARANT
Isabelle
(MCF)

HARANT Isabelle (MCF)

harant.i@chu-toulouse.fr

LARROUY
Dominique
(MCF)

LARROUY Dominique (MCF)

dominique.larrouy@inserm.fr

05 61 32 56 31

MOUISEL
Etienne
(MCF)

MOUISEL Etienne (MCF)

etienne.mouisel@inserm.fr

05 61 32 56 26

Etienne MOUISEL, Ph.D.
Born on August 10, 1979

Education

2007 Ph.D., Physiology, University of Evry Val d’Essonne, France
2003 M.S., Physiology, University of Paris Descartes, France
2001 B.S., Sports Science School, University of Paris Descartes, France

Scientific Career

2011-present Assistant Professor, Physiology, University of Toulouse - INSERM UMR 1048, France
2007-2011 Post-Doctoral Fellow (Mentor: Helge Amthor, M.D, Professor), Paris, France
Myology Institute, Therapies of striated muscle disorders Laboratory, Paris, France
2003-2007 Ph.D. Fellow, Evry, France
Molecular Neurogenetics Laboratory (Mentor: Judith Melki, M.D, Professor)
Exercise Physiology Laboratory (Mentor: Véronique Billat, Professor)

Training and expertise

Supervisor of 1 PhD student and 5 Master students
25 original articles, 1 review, 1 book chapter
CASPAR-BAUGUIL
Sylvie
(MCU-PH)

CASPAR-BAUGUIL Sylvie (MCU-PH)

casparbauguil.s@chu-toulouse.fr

05 61 32 56 31

Sylvie Caspar-Bauguil, Pharm. D., Ph.D.
Associate professor of Nutrition and Medical Biochemistry, Purpan Faculty of Medicine, Toulouse, France

Education

2008 Habilitation (HDR), Pathophysiology, University of Toulouse, France
1993 Ph.D., Immunology, University of Toulouse, France
1989 M.S., Human Physiology, University of Toulouse, France
1987 Doctor in Pharmacy, University of Nancy, France

Scientific Career

2010- Associate professor of Nutrition and Medical Biochemistry
2004-2009 University hospital Assistant (Mentors: Luc Pénicaud and Louis Casteilla), CNRS-UMR 5241 Neurobiology, tissular plasticity and energy metabolism
2002-2004 Group of nutrition research (GREEN), university team, Toulouse
1995-2000 Post-Doctoral Fellow (Mentor: Hervé Benoist, M.D, Professor), Inserm U466 Lipids and atherosclerosis , Toulouse, France

Hospital duties (current)

Biologist of the Department of Clinical and Nutritional Biochemistry, Toulouse University Hospitals. Head of the phospholipid fatty acid analysis sector.
Teaching and Training
Courses in biochemistry, nutrition and medical research (medical and scientific studies)
Supervisor of >30 students.

Expertise and membership

42 original scientific articles, 2 reviews, 2 book chapters
SIGAPS: 524
Reviewer for scientific journals (Cell biology and toxicology, Clinical biochemistry, International journal of molecular science, International journal of obesity, Journal of cellular biochemistry, journal of physiology and biochemistry, PLOS one).
Member of the national committee of experts (AERES) in 2011.
Member of the French society of study and research on obesity (AFERO), the Francophone society of nutrition (SFN), the French society of vitamins and biofactors (SFVB) and colleges of nutrition and biochemistry teachers (CEN and CNBBMM).
Member of the faculty council of Purpan faculty of medicine, Toulouse (France), of the National Universities Council (CNU 4404, assessor of the 44 section) and of scientific committee of the lipidomic platform of I2MC.

Awards

1995, "recherche et partage" association
1994, French National Cancer League
1992, Paul Sabatier university allocation (ATUPS)
DEGLISEZINSKI
Isabelle
(MCU-PH)

DEGLISEZINSKI Isabelle (MCU-PH)

deglisezinski.i@chu-toulouse.fr

05-67-77-16-90

Médecin du sport

Exploration de la fonction respiratoire et médecine du sport - Pôle voies respiratoires
Hôpital Larrey
24, chemin de Pouvourville - TSA 30030
31059 Toulouse cedex 9
MONTASTIER
Emilie
(MCU-PH)

MONTASTIER Emilie (MCU-PH)

Emilie.Simerman@inserm.fr

05-67-77-16-38

Médecin nutritionniste

Endocrinologie, maladies métaboliques et nutrition
Pôle cardiovasculaire et métabolique
Hôpital Larrey
24, chemin de Pouvourville - TSA 30030
31059 Toulouse cedex 9
THALAMAS
Claire
(MCU-PH)

THALAMAS Claire (MCU-PH)

claire.thalamas@inserm.fr

05 61 77 91 03

Praticien Hospitalier-Pharmacologie Clinique
Médecin responsable du Centre d'Investigation Clinique de Toulouse

Expertise: recherche clinique- conception, méthodologie et montage de projet, coordination d'études multicentriques, réalisation des essais au sein d'une plateforme autorisée phase 1 (8 lits d'investigations).

http://www.chu-toulouse.fr/-c-i-c-centre-d-investigation

Hôpital Pierre Paul Riquet
Hall D 2ième étage
Hôpital Purpan
Place du Dr Baylac
TSA40031
31059 TOULOUSE CEDEX 9
BONNEL
Sophie
(IE)

BONNEL Sophie (IE)

sophie.bonnel@inserm.fr

05 61 32 56 30

LEFORT
Corinne
(IE)

LEFORT Corinne (IE)

corinne.lefort@inserm.fr

05 61 32 56 27

MAIRAL
Aline
(IE)

MAIRAL Aline (IE)

aline.mairal@inserm.fr

05 61 32 56 30

MONBRUN
Laurent
(AI)

MONBRUN Laurent (AI)

laurent.monbrun@inserm.fr

05 61 32 56 25

MIR
Lucile
(AI)

MIR Lucile (AI)

lucile.mir@inserm.fr

05 61 32 56 27

MARQUES
Marie-Adeline
(TE)

MARQUES Marie-Adeline (TE)

marie.marques@inserm.fr

05 61 32 56 27

MONGE-ROFFARELLO
Boris
(Post-doc)

MONGE-ROFFARELLO Boris (Post-doc)

boris.monge-roffarello@inserm.fr

05 61 32 56 30

IMBERT
Alyssa
(Doctorante)

IMBERT Alyssa (Doctorante)

MORIGNY
Pauline
(Doctorante)

MORIGNY Pauline (Doctorante)

pauline.morigny@inserm.fr

05 61 32 56 25

Le laboratoire de Recherche sur les Obésités explore les conséquences de l'excès de masse grasse observé dans l'obésité et cherche à comprendre les déterminants biologiques et les mécanismes moléculaires des complications métaboliques liées à l'obésité dont en particulier le diabète de type 2. Nous avons étudié de nouveaux aspects du métabolisme des acides gras dans le tissu adipeux et le muscle squelettique, mais aussi les liens entre les voies métaboliques, voies inflammatoires et fibrose et leurs relations avec la lipotoxicité et la résistance à l'insuline. En utilisant une approche translationnelle (Bedside-to-Bench), nous avons pu montrer que la modulation de la lipolyse du tissu adipeux et du muscle squelettique impacte l'oxydation des graisses, la lipotoxicité et la sensibilité à l'insuline.

Des études chez l'Homme et la souris ont montré qu'une intervention pharmacologique (inhibition de la lipolyse, traitement par des peptides natriurétiques) ou sur le mode de vie (exercice physique, régime hypocalorique) améliore les fonctions du tissu adipeux et du muscle squelettique et la sensibilité à l'insuline de l'organisme. Dans les cellules adipeuses, l'inhibition de la lipolyse ou l'activation de l'oxydation des acides gras montrent des effets bénéfiques en limitant le relargage d'acides gras dans la circulation sanguine et par une modulation intrinsèque du métabolisme du glucose. Dans le muscle squelettique, la régulation du métabolisme des triglycérides intramyocytaires par des lipases et de l'oxydation des acides gras par les peptides natriurétiques protègent contre le rôle délétère de l'excès d'acides gras circulants dans l'obésité.

Notre objectif général est maintenant d'élucider les mécanismes cellulaire et moléculaire associant le métabolisme des acides gras et du glucose au niveau des tissus et de l'organisme, et d'évaluer le potentiel thérapeutique de l'inhibition de la lipolyse du tissu adipeux et l'activation de l'oxydation des acides gras dans le muscle squelettique et le tissu adipeux.

Schéma intégratif de notre problématique de recherche:

schema integratif Eq4

Retombées attendues en santé

Les résultats de nos projets peuvent contribuer à:

- Valider l'inhibition chronique de la lipolyse dans le tissu adipeux comme stratégie thérapeutique efficace pour lutter contre la résistance à l'insuline
- Valider l'utilisation de molécules modulant l'action des peptides natriurétiques dans le tissu adipeux et le muscle squelettique
- Identifier des biomarqueurs pour caractériser les patients qui répondront le mieux à ces stratégies thérapeutiques (théragnostique)
- Développer des thérapies combinant une restriction calorique ou un exercice physique et un traitement pharmacologique avec une molécule antilipolytique ou des peptides natriurétiques.
 

Actualités

Une nouvelle piste pour prévenir le diabète

Intervention de Dominique LANGIN sur LCI: Video LCI

miRDiet : Un projet Européen sur les microARNs comme nouveaux marqueurs nutritionnels

Nathalie Viguerie et Dominique Langin présentent le programme miRDiet: Vidéo JPI