Team members

LANGIN
Dominique
(PU-PH)

LANGIN Dominique (PU-PH)

dominique.langin@inserm.fr

05 61 32 56 28

LANGIN Dominique
Born: 13th december 1962
E-mail address: dominique.langin@inserm.fr

• EDUCATION
2006 Certifications in Clinical Biochemistry & Human Genetic Testing, Toulouse University Hospitals
1993 Capacity to Supervise Research Programs, University Toulouse III-Paul Sabatier
1990 Doctor of Science (PhD), University Toulouse III-Paul Sabatier. With honors
1988 Doctor in Veterinary Medicine (DVM) National Veterinary School of Nantes. Faculty of Medicine, Nantes. With honors
1987 Diploma for Advanced Level Studies (M2R). University of Rennes. National Agronomic School of Rennes. Ranked first
1986 Certificate of Veterinary Medicine Practice. National Veterinary School of Nantes

• CURRENT POSITION
2006-pres. Professor, University Toulouse III-Paul Sabatier, Faculty of Medicine & University Hospitals.

• PREVIOUS POSITIONS
2000-2006 Director of Research at Inserm (National Institute of Health and Medical Research). Toulouse
1993-2000 Established Investigator at CNRS (National Center for Scientific Research). Toulouse, France
1990-1993 Visiting Scientist of the Swedish Medical Research Council & Research Associate, Faculty of Medicine, Lund University
1987-1990 Research Investigator, INRA (National Institute of Agronomic Research). Clermont-Ferrand
1986-1987 Lecturer, Department of Nutrition, National Veterinary School of Nantes

• FELLOWSHIPS AND AWARDS
2014 Appointment as Senior member of Institut Universitaire de France
2011 Friedrich Wassermann Life Time Achievement Award, European Association for the Study of Obesity
1998 Andre Mayer Award, International Association for the Study of Obesity
1996 Young Investigator Award, European Association for the Study of Obesity

• SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS
Since 1994, direct supervision of 12 post-doctoral fellows, 17 PhD students and 21 MSc students

• TEACHING ACTIVITIES
Bachelor’s level: human genome and molecular biology (responsible), biochemistry, medical research
Master’s and Doctorate levels: metabolic diseases, genomics
Faculty of Medicine, University Toulouse III-Paul Sabatier and Toulouse University Hospitals

• HOSPITAL DUTIES
Genetic testing of monogenic forms of diabetes, Toulouse University Hospitals

• INSTITUTIONAL RESPONSIBILITIES (current)
-Head of the Obesity Research Laboratory & Deputy Director. Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm-University Toulouse III-Paul Sabatier
- Co-director with Prof. Vladimir Stich of the Franco-czech laboratory for clinical research on obesity
-Scientific board of Toulouse Metabolomic, Fluxomic and Lipidomic platform consortium


• COMMISSIONS OF TRUST (current)
- Scientific Advisory Board of the SFB Lipid Hydrolysis, Austrian Science Fund, University of Graz
- Evaluation Committee of the European Foundation for the Study of Diabetes Novo Nordisk program
- Scientific Advisory Board of the Diabetes Program from the Karolinska Institute

• EDITORIAL ACTIVITIES
Past member of the editorial boards in Diabetes, International Journal of Obesity and Journal of Nutrigenetics and Nutrigenomics.
Reviewer for Nature, Nature Med., New Engl. J. Med., Nature Commun., Cell Metab., PLoS Biol., PLoS Genet., Proc. Natl. Acad. Sci. USA, J. Clin. Invest., Genes Dev., Diabetes, Diabetologia,…

• PUBLICATIONS AND CITATION REPORT (Thomson Reuters Web of Science May 2019)
233 original articles and 72 review articles. 14200 sum of times cited without self-citations. h index 68


• COORDINATION OF RESEARCH PROJECTS
European projects:
2018-pres. Project board of @OBEDIS (JPI A Healthy Diet for a Healthy Life)
2016-2018 Coordinator of JPI A Healthy Diet for a Healthy Life program miRDiet (Circulating microRNAs as markers of dietary intake)
2008-2011 Project board of the FP7 project ‘ADAPT: Adipokines as Drug Targets to Combat Adverse Effects of Excess Adipose Tissue’
2005-2010 Project board of the FP6 project ‘Hepadip: Hepatic and adipose tissue and functions in the metabolic syndrome’
2005-2009 Group leader for Functional Genomics and Project Board in the FP6 project DIOGENES ‘Diet, Obesity and genes’
2001-2004 Group leader for Gene Expression and Project Board in the FP5 project NUGENOB ‘Nutrient-gene interaction in human obesity’
1999-2001 Coordinator of the EU FAIR project FATLINK ‘Dietary fat, body weight control and links between obesity and cardiovascular disease’
1994-1997 Coordinator the BIOMED I project EUROLIP 'Impairment of adipose tissue metabolic regulation as a generator of risk factors for cardiovascular disease'
National projects:
2018-pres. Coordinator of the Project Hepadialogue (French National Research Agency)
2014-2018 Project board of FORCE (French Obesity Research Center of Excellence, F-CRIN)
2013-2017 Coordinator of the Project Obelip (French National Research Agency)
2012-2014 Coordinator of a prospective task force to establish a roadmap on the future of obesity research in France (French National Research Agency, Inserm)
2009-2012 Coordinator of the Project Lipob (French National Research Agency)

• EVALUATION OF RESEARCH PROJECTS (selected)
-European Commission: European Research Council, FP6, FP7 and Horizon 2020
-Fondation Leducq, USA-Europe -European Foundation for the Study of Diabetes
-Wallenberg Foundation, Sweden -Swiss National Science Fund
-Medical Research Council & Wellcome Trust, UK -FWF, Austria
-French National Research Agency, Inserm, CNRS & Fondation pour la Recherche Médicale,…, France

• MEMBERSHIPS OF SCIENTIFIC SOCIETIES (current)
International (IASO), European (EASO) and French (AFERO) Associations for the Study of Obesity
French-speaking (SFD) and European (EASD) Associations for the Study of Diabetes
MORO
Cédric
(CRCN)

MORO Cédric (CRCN)

cedric.moro@inserm.fr

05 61 32 56 26

Cedric MORO, Ph.D.
Born on September 26, 1978

Education

2012 Habilitation (HDR), Pathophysiology, University of Toulouse, France
2005 Ph.D., Physiology, University of Toulouse, France
2002 M.S., Integrative Physiology, University of Lyon, France
2000 B.S., Cellular Biology and Physiology, University of Toulouse, France

Scientific Career

2016-present Co-director of the Obesity Research Laboratory, INSERM UMR 1048, Toulouse, France

2013-present Principal Investigator 1st class, INSERM UMR 1048, Toulouse, France

2009-2013 Principal Investigator 2nd class, INSERM UMR 1048, Toulouse, France

2007-2009 Instructor Research, John McIllheny Skeletal muscle Physiology Laboratory,
Pennington Biomedical Research Center, Baton Rouge, USA

2006-2007 Post-Doctoral Fellow (Mentor: Steven R. Smith, M.D, Professor)
Pennington Biomedical Research Center, Molecular and Experimental Endocrinology Laboratory, Baton Rouge, Louisiana, USA

2005-2006 Post-Doctoral Fellow (Mentor: Dominique Langin, D.V.M, Ph.D, Professor)
Obesity Research Unit, National Institute of Health and Medical Research (INSERM) U586, Toulouse, France; and Franco-Czech laboratory for clinical research on obesity, Prague, Czech Republic.

Training and expertise

Supervisor of 3 PhD students and >10 Master students.

70 original articles, 11 reviews, 3 book chapters

Reviewer for several funding agencies (Diabetes UK, IDEX and CORDDIM Ile de France, AFM-Téléthon, ANRT, FWF, Fond Suisse, ERC, Deutch Diabetes Foundation, Croatian Science Foundation, Fond Belge...) and Journals (Mol Metab, Cell Reports, Diabetes...).

Awards

2008 Ethan Sims Young Investigator Award Finalist (The Obesity Society)
2007 “Rose Lamarca” Award for Clinical Research, (Fondation pour la Recherche
Médicale)
2007 Young Investigator Award of the European Association for the Study of Obesity
2006 Post-doctoral Fellowship Lavoisier, Egide foundation
2004 Award of the French Association of Physiologists
DENECHAUD
Pierre-Damien
(CRCN)

DENECHAUD Pierre-Damien (CRCN)

TAVERNIER
Geneviève
(CRCN)

TAVERNIER Geneviève (CRCN)

genevieve.tavernier@inserm.fr

05 61 32 56 26

Geneviève TAVERNIER, Ph.D.

Education

1996 Ph.D, Physiopathology, Paul Sabatier University, Toulouse, France
1991 M.S., Human Physiopathology, Paul Sabatier University, Toulouse, France

Scientific Career

1998-present : scientific investigator from CNRS at the National Institute of Health and Medical Research, UMR1048 Inserm/Paul Sabatier University, Toulouse, France
1996 to 1998 : postdoctoral fellow at the Cochin Institute for Molecular Genetics (Mentors Dominique Daegelen and Jean-Paul Concordet), Paris, France
2011-2016 : deputy director of the UMS006/CREFRE Inserm/Paul Sabatier University, Toulouse, France
2011-present : head of the transgenic core facility of the UMS006/CREFRE Inserm/Paul Sabatier University, Toulouse, France

Training, expertise and membership

Co-instructor of 4 PhD students and of around 10 master students.
1999-present : teaching in Master of Research and Professional Master at the Paul Sabatier University, Toulouse, France
42 original scientific articles
Reviewer for scientific journals

2008-present : Life Science et European Journal of Endocrinology.
2016 : Journal of Genetics and Genomics
2007-2016 : ROCAD french network, work package nb8 “New technical approaches in transgenesis”
2012-2016 : ROCAD french network, work package nb10 “Resources and developments in mutagenesis and transgenesis”
2013-2016 : Celphedia Research Infrastructure (la Création l’ELevage le PHEnotypage la DIstribution l’Archivage), workpackage « Mutagenesis to create, validate and improve new technical tools such as TaleN and CrispR)
2016-present : member of the Celphedia/Réseau network, 2 work packages : “genetic engineering” and “ES cells and microinjection”
2014-present : member of the local ethical committee for animal experimentation nb CEEA122 of the UMS006/Crefre. Member of the scientific council of the VibioSphen biotech.
VIGUERIE
Nathalie
(CRCN)

VIGUERIE Nathalie (CRCN)

nathalie.viguerie@inserm.fr

05 61 32 56 31

BOURLIER
Virginie
(MCF)

BOURLIER Virginie (MCF)

virginie.bourlier@inserm.fr

05 61 32 56 26

Virginie BOURLIER, Ph.D.
Born on March 30, 1972

Education
1999 Ph.D, Biology, Joseph Fourier University, Grenoble, France
1995 M.S., Cellular and Molecular Biology, Joseph Fourier University, Grenoble, France
1993 B.S., Cellular Biology and Physiology, Joseph Fourier University, Grenoble, France

Scientific Career
2001-… Associate professor, UMR 1048 INSERM/Paul Sabatier University, Toulouse, France
1999-2001 Post-Doctoral Fellow/Research Associate (Mentor: Dr. Walter Boyle, M.D, Professor), Washington University School of Medecine, Department of Anesthesiology, St Louis, MO, USA.

Training, expertise and membership
Supervisor of 2 PhD students and >10 Master students.
29 original scientific articles.
Reviewer for scientific journals (PLoS One, Stem Cells Int, Int. J Obes, J Clin Endocrinol Metab...).
Member of the French society of study and research on obesity (AFERO) and the French-speaking society of diabetes (SFD/ALFEDIAM)
Reviewer for research proposal calls of the Federal Toulouse University Midi-Pyrénées (COMUE, 2014-2016).
Member of academic council of Paul Sabatier University (2011-2015), Toulouse, France.

Awards/Fundings
2007, Paul Sabatier University bonus quality research (BQR) allocation
2009, ALFEDIAM / Roche Diagnostic allocation
2013, Paul Sabatier University bonus quality research (BQR) allocation
HARANT
Isabelle
(MCF)

HARANT Isabelle (MCF)

harant.i@chu-toulouse.fr

05 67 77 16 94

Maître de Conférences STAPS

Service d'Exploration de la Fonction Respiratoire et de Médecine du Sport
Hôpital Larrey
24 Chemin de Pouvourville - TSA - 30030
31059 TOULOUSE Cedex 9
LARROUY
Dominique
(MCF)

LARROUY Dominique (MCF)

dominique.larrouy@inserm.fr

05 61 32 56 31

Maître de Conférence Physiologie

MOUISEL
Etienne
(MCF)

MOUISEL Etienne (MCF)

etienne.mouisel@inserm.fr

05 61 32 56 26

Etienne MOUISEL, Ph.D.
Born on August 10, 1979

Education

2007 Ph.D., Physiology, University of Evry Val d’Essonne, France
2003 M.S., Physiology, University of Paris Descartes, France
2001 B.S., Sports Science School, University of Paris Descartes, France

Scientific Career

2011-present Assistant Professor, Physiology, University of Toulouse - INSERM UMR 1048, France
2007-2011 Post-Doctoral Fellow (Mentor: Helge Amthor, M.D, Professor), Paris, France
Myology Institute, Therapies of striated muscle disorders Laboratory, Paris, France
2003-2007 Ph.D. Fellow, Evry, France
Molecular Neurogenetics Laboratory (Mentor: Judith Melki, M.D, Professor)
Exercise Physiology Laboratory (Mentor: Véronique Billat, Professor)

Training and expertise

Supervisor of 1 PhD student and 5 Master students
25 original articles, 1 review, 1 book chapter
CASPAR-BAUGUIL
Sylvie
(MCU-PH)

CASPAR-BAUGUIL Sylvie (MCU-PH)

casparbauguil.s@chu-toulouse.fr

05 61 32 56 31

Sylvie Caspar-Bauguil, Pharm. D., Ph.D.
Associate professor of Nutrition and Medical Biochemistry, Purpan Faculty of Medicine, Toulouse, France

Education

2008 Habilitation (HDR), Pathophysiology, University of Toulouse, France
1993 Ph.D., Immunology, University of Toulouse, France
1989 M.S., Human Physiology, University of Toulouse, France
1987 Doctor in Pharmacy, University of Nancy, France

Scientific Career

2010- Associate professor of Nutrition and Medical Biochemistry
2004-2009 University hospital Assistant (Mentors: Luc Pénicaud and Louis Casteilla), CNRS-UMR 5241 Neurobiology, tissular plasticity and energy metabolism
2002-2004 Group of nutrition research (GREEN), university team, Toulouse
1995-2000 Post-Doctoral Fellow (Mentor: Hervé Benoist, M.D, Professor), Inserm U466 Lipids and atherosclerosis , Toulouse, France

Hospital duties (current)

Biologist of the Department of Clinical and Nutritional Biochemistry, Toulouse University Hospitals. Head of the phospholipid fatty acid analysis sector.
Teaching and Training
Courses in biochemistry, nutrition and medical research (medical and scientific studies)
Supervisor of >30 students.

Expertise and membership

42 original scientific articles, 2 reviews, 2 book chapters
SIGAPS: 524
Reviewer for scientific journals (Cell biology and toxicology, Clinical biochemistry, International journal of molecular science, International journal of obesity, Journal of cellular biochemistry, journal of physiology and biochemistry, PLOS one).
Member of the national committee of experts (AERES) in 2011.
Member of the French society of study and research on obesity (AFERO), the Francophone society of nutrition (SFN), the French society of vitamins and biofactors (SFVB) and colleges of nutrition and biochemistry teachers (CEN and CNBBMM).
Member of the faculty council of Purpan faculty of medicine, Toulouse (France), of the National Universities Council (CNU 4404, assessor of the 44 section) and of scientific committee of the lipidomic platform of I2MC.

Awards

1995, "recherche et partage" association
1994, French National Cancer League
1992, Paul Sabatier university allocation (ATUPS)
DEGLISEZINSKI
Isabelle
(MCU-PH)

DEGLISEZINSKI Isabelle (MCU-PH)

deglisezinski.i@chu-toulouse.fr

05-67-77-16-90

Médecin du sport

Exploration de la fonction respiratoire et médecine du sport - Pôle voies respiratoires
Hôpital Larrey
24, chemin de Pouvourville - TSA 30030
31059 Toulouse cedex 9
MONTASTIER
Emilie
(MCU-PH)

MONTASTIER Emilie (MCU-PH)

Emilie.Simerman@inserm.fr

05-67-77-16-38

Médecin nutritionniste

Endocrinologie, maladies métaboliques et nutrition
Pôle cardiovasculaire et métabolique
Hôpital Larrey
24, chemin de Pouvourville - TSA 30030
31059 Toulouse cedex 9
THALAMAS
Claire
(MCU-PH)

THALAMAS Claire (MCU-PH)

claire.thalamas@inserm.fr

05 61 77 91 03

Praticien Hospitalier-Pharmacologie Clinique
Médecin responsable du Centre d'Investigation Clinique de Toulouse

Expertise: recherche clinique- conception, méthodologie et montage de projet, coordination d'études multicentriques, réalisation des essais au sein d'une plateforme autorisée phase 1 (8 lits d'investigations).

http://www.chu-toulouse.fr/-c-i-c-centre-d-investigation

Hôpital Pierre Paul Riquet
Hall D 2ième étage
Hôpital Purpan
Place du Dr Baylac
TSA40031
31059 TOULOUSE CEDEX 9
BIETH
Eric
(MCU-PH)

BIETH Eric (MCU-PH)

MAIRAL
Aline
(IE)

MAIRAL Aline (IE)

aline.mairal@inserm.fr

05 61 32 56 30

MONBRUN
Laurent
(AI)

MONBRUN Laurent (AI)

laurent.monbrun@inserm.fr

05 61 32 56 25

MARQUES
Marie-Adeline
(TE)

MARQUES Marie-Adeline (TE)

marie.marques@inserm.fr

05 61 32 56 27

MONGE-ROFFARELLO
Boris
(Post-doc)

MONGE-ROFFARELLO Boris (Post-doc)

boris.monge-roffarello@inserm.fr

05 61 32 56 30

CARPER
Deborah
(Doctorante)

CARPER Deborah (Doctorante)

deborah.carper@inserm.fr

05 61 32 56 30

RECAZENS
Emeline
(Doctorante)

RECAZENS Emeline (Doctorante)

emeline.recazens@inserm.fr

05 61 32 56 30

VION
Julie
(Doctorante)

VION Julie (Doctorante)

julie.vion@inserm.fr

05 61 32 56 30

DUFAU
Jérémy
(Doctorant)

DUFAU Jérémy (Doctorant)

               The Obesity Research Laboratory works on the consequences of the excess of fat mass observed in obesity and aims at understanding the biological determinants and molecular mechanisms of obesity-related metabolic complications with a special emphasis on type 2 diabetes.

We have studied novel aspects of fatty acid metabolism in adipose tissue and skeletal muscle as well as the links between metabolic, inflammatory and fibrotic pathways and their relationship with lipotoxicity and insulin resistance. Using a bedside-to-bench approach, we have shown that modulation of adipose tissue and skeletal muscle lipolysis impacts on fat oxidation, lipotoxicity and insulin sensitivity. Studies in mice and humans revealed that pharmacological (inhibition of lipolysis, treatment with natriuretic peptides) and lifestyle (physical exercise, low calorie diet) interventions improve adipose tissue and skeletal muscle function as well as whole-body insulin sensitivity. In fat cells, inhibition of lipolysis or activation of fatty acid oxidation shows beneficial effects by limiting fatty acid release into blood circulation and by intrinsic modulation of glucose metabolism. Moreover, recent studies revealed a physival interaction between one of the fat cell neutral lipase and a transcription factor governing insulin signaling independently of lipolysis. In skeletal muscle, the regulation of intramyocellular triglyceride metabolism by lipases and of fatty acid oxidation by natriuretic peptides may be protective against the deleterious role of excess circulating fatty acids in obesity.

Our overall objective is now to decipher the cellular and molecular mechanisms associating fatty acid and glucose metabolisms at tissue and whole body levels and to evaluate the therapeutic potential of the inhibition of adipose tissue lipolysis/lipases and activation of skeletal muscle and adipose tissue fatty acid oxidation.

OverviewObesityresLab