Membres de l'équipe

Nègre-Salvayre
Anne
(DR1)

Nègre-Salvayre Anne (DR1)

anne.negre-salvayre@inserm.fr

33(0)561322059




Present position
- DR1 CNRS
- Team leader: Lipid peroxidation and signaling in vascular diseases
- Deputy director INSERM U1048 - Institute of Metabolic and Cardiovascular Diseases

University degrees
- Pharmacist Toulouse 1976
- Graduated in Clinical Biology Toulouse 1980
- Doctorate in Pharmaceutical Sciences - Toulouse 1983
- PhD (Human Biology) - Toulouse 1987
- Research Supervisor - Toulouse 1992

Scientific career
1983-1988 Post-doctoral fellow, Hadassah Medical School Jerusalem, Israel
1985-2001: Established investigator (CR2 and CR1) INSERM U101 and INSERM U466 Toulouse
2001-2009: Senior researcher (Directeur de Recherche) CNRS DR2
2009-running: Senior researcher (Directeur de Recherche) CNRS DR1
2007-2010: Head of Team 10 "Atherosclerosis and graft arteriosclerosis", INSERM U858 - Toulouse
2011-2015: Head of Team 10 "Atherosclerosis and graft arteriosclerosis", INSERM UMR1048 - Toulouse
Running: Head of the Team10 "Lipid Peroxidation and signaling in Vascular Diseases", INSERM U 1048
Since 2016: Deputy director INSERM U1048

Hospital duties
1978-1985: Fellow and Instructor, Medical Biochemistry Laboratory, CHU Purpan Toulouse

Teaching and Training
1982-1983: Assistant Professor in Medical Physiology, Faculty of Medicine Rangueil, Toulouse
1981-1982: Instructor, Biochemistry Department, Faculty of Medicine Purpan, Toulouse
1974-1976: Instructor, Biochemistry Department, Faculty of Pharmacy, Toulouse

Scientific activities and expertise
Membership of learned societies: New Society for French Atherosclerosis (NSFA), Society for Free Radical Diseases (SFRR), HNE-Club, Oxygen Club of california (OCC), British Pharmacological Society

Associate Editor "The British Journal of Pharmacology"
Vindis
Cécile
(DR2)

Vindis Cécile (DR2)

cecile.vindis@inserm.fr

33(0)561322705

Augé
Nathalie
(CR1)

Augé Nathalie (CR1)

nathalie.auge@inserm.fr

33(0)561323421

Bernis
Corinne
(TR)

Bernis Corinne (TR)

corinne.bernis@inserm.fr

33(0)561323421

Bonneville
Jonathan
(Doc)

Bonneville Jonathan (Doc)

jonathan.bonneville@inserm.fr

33(0)561323391

Camaré
Caroline
(AHU)

Camaré Caroline (AHU)

caroline.camare@inserm.fr

33(0)561322061

Faccini
Julien
(IE-CDD)

Faccini Julien (IE-CDD)

julien.faccini@inserm.fr

33(0)561322705

Geoffre
Nancy
(AJT 50%)

Geoffre Nancy (AJT 50%)

nancy.geoffre@inserm.fr

33(0)561323421

Guerby
Paul
(Doc)

Guerby Paul (Doc)

paul.guerby@inserm.fr

33(0)561323510

Ingueneau
Cécile
(MCU-PH)

Ingueneau Cécile (MCU-PH)

ingueneau.c@chu-toulouse.fr

33(0)561323447

Meyer
Elbaz
(PU-PH)

Meyer Elbaz (PU-PH)

elbaz.m@chu-toulouse.fr

33(0)561322705

Meyrignac
Olivier
(PH)

Meyrignac Olivier (PH)

meyrignac.o@chu-toulouse.fr

Moreno
Ramiro
(IR-CDD)

Moreno Ramiro (IR-CDD)

ramiro.moreno@inserm.fr

Moulis
Manon
(Post-Doc)

Moulis Manon (Post-Doc)

manon.moulis@inserm.fr

33(0)561323391

Nahapetyan
Hripsimé
(Doc)

Nahapetyan Hripsimé (Doc)

hripsime.nahapetyan@inserm.fr

33(0)561322705

Rouahi
Myriam
(IE)

Rouahi Myriam (IE)

myriam.rouahi@inserm.fr

33(0)561322061

Rousseau
Hervé
(PU-PH)

Rousseau Hervé (PU-PH)

rousseau.h@chu-toulouse.fr

Salvayre
Robert
(PU-PH EM)

Salvayre Robert (PU-PH EM)

robert.salvayre@inserm.fr

33(0)562323148

Santiago
Christophe
(AJT 50%)

Santiago Christophe (AJT 50%)

christophe.santiago@inserm.fr

33(0)561323421

Sewonu
Anou
(IR-CDD)

Sewonu Anou (IR-CDD)

kwadzo.sewonu@inserm.fr

Swiader
Audrey
(AI)

Swiader Audrey (AI)

audrey.swiader@inserm.fr

33(0)561323510

PMIDTitreAuteursAnnéeJournal
27119505Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsSwiader A, Nahapetyan H, Faccini J, D Angelo R, Mucher E, Elbaz M, Boya P, Vindis C2016Oncotarget
26855418The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDLCamare C, Auge N, Pucelle M, Saint-Lebes B, Grazide MH, Negre-Salvayre A, Salvayre R2016Free Radic Biol Med
26717905Oxidative theory of atherosclerosis and antioxidants.Salvayre R, Negre-Salvayre A, Camaré C.2016Biochimie.
25411381Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophyLaurent AC, Bisserier M, Lucas A, Tortosa F, Roumieux M, De Regibus A, Swiader A, Sainte-Marie Y, Heymes C, Vindis C, Lezoualc h F2015Cardiovasc Res
25176316Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibodyCamare C, Trayssac M, Garmy-Susini B, Mucher E, Sabbadini R, Salvayre R, Negre-Salvayre A2015Br J Pharmacol
25574848Annexin II-dependent actin remodelling evoked by hydrogen peroxide requires the metalloproteinase sphingolipid pathwayCinq-Frais C, Coatrieux C, Savary A, D Angelo R, Bernis C, Salvayre R, Negre-Salvayre A, Auge N 2015Redox Biol
25555205Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDLGaroby-Salom S, Rouahi M, Mucher E, Auge N, Salvayre R, Negre-Salvayre A2015Redox Biol
25739050Elastin Modification by 4-Hydroxynonenal in Hairless Mice Exposed to UV-A. Role in Photoaging and Actinic ElastosisLarroque-Cardoso P, Camare C, Nadal-Wollbold F, Grazide MH, Pucelle M, Garoby-Salom S, Bogdanowicz P, Josse G, , Schmitt AM, Uchida K, Zarkovic K, Salvayre R, Nègre-Salvayre A2015J Invest Dermatol
25537552Autophagy: an emerging therapeutic target in vascular diseases.Vindis C2015 Br J Pharmacol
25930666Role of Sphingosine-1-Phosphate in Transplant Vasculopathy Evoked by Anti-HLA Antibody. Trayssac M, Galvani S, Auge N, Sabbadini R, Calise D, Mucher E, Sallusto F, Thomsen M, Salvayre R, Negre-Salvayre A2015Am J Transplant
245615794-Hydroxynonenal impairs transforming growth factor-beta1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblastsLarroque-Cardoso P, Mucher E, Grazide MH, Josse G, Schmitt AM, Nadal-Wolbold F, Zarkovic K, Salvayre R, Negre-Salvayre A2014Free Radic Biol Med
23083489Protein disulfide isomerase modification and inhibition contribute to ER stress and apoptosis induced by oxidized low density lipoproteins. Antioxid Redox Signal Muller C, Bandemer J, Vindis C, Camare C, Mucher E, Gueraud F, Larroque-Cardoso P, Bernis C, Auge N, Salvayre R, Negre-Salvayre A 2013Antioxid Redox Signal
23651497A signaling cascade mediated by ceramide, src and PDGFRbeta coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1Cinq-Frais C, Coatrieux C, Grazide MH, Hannun YA, Negre-Salvayre A, Salvayre R, Auge N2013Biochim Biophys Acta
23449456Role of protein kinase C delta in ER stress and apoptosis induced by oxidized LDL in human vascular smooth muscle cellsLarroque-Cardoso P, Swiader A, Ingueneau C, Negre-Salvayre A, Elbaz M, Reyland ME, Salvayre R, Vindis C2013Cell Death Dis
21820441Serotonin 5-HT2A receptor-mediated hypertrophy is negatively regulated by caveolin-3 in cardiomyoblasts and neonatal cardiomyocytes. J Mol Cell Cardiol Mialet-Perez J, D Angelo R, Villeneuve C, Ordener C, Negre-Salvayre A, Parini A, Vindis C2012J Mol Cell Cardiol
21043830Antiatherogenic effect of bisvanillyl-hydralazone, a new hydralazine derivative with antioxidant, carbonyl scavenger, and antiapoptotic properties. Bouguerne B, Belkheiri N, Bedos-Belval F, Vindis C, Uchida K, Duran H, Grazide MH, Baltas M, Salvayre R, Negre-Salvayre A2011Antioxid Redox Signal
22082680A key role for matrix metalloproteinases and neutral sphingomyelinase-2 in transplant vasculopathy triggered by anti-HLA antibody. Galvani S, Trayssac M, Auge N, Thiers JC, Calise D, Krell HW, Sallusto F, Kamar N, Rostaing L, Thomsen M , Negre-Salvayre A, Salvayre R.2011Circulation
21412049Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: prevention by HDLs. Muller C, Salvayre R, Negre-Salvayre A, Vindis C2011Autophagy
21113143 HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs. Muller C, Salvayre R, Negre-Salvayre A, Vindis C2011Cell Death Differ
19106412Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. Sanson M, Auge N, Vindis C, Muller C, Bando Y, Thiers JC, Marachet MA, Zarkovic K, Sawa Y, Salvayre R, Negre-Salvayre, A.2009Circ Res