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@article{ISI:000631179600002,

title = {Organismal roles for the PI3K alpha and beta isoforms: their 

 specificity, redundancy or cooperation is context-dependent},

author = {Silvia Arcucci and Fernanda Ramos-Delgado and Coralie Cayron and Nicole Therville and Marie-Pierre Gratacap and Celine Basset and Benoit Thibault and Julie Guillermet-Guibert},

doi = {10.1042/BCJ20210004},

issn = {0264-6021},

year  = {2021},

date = {2021-03-01},

journal = {BIOCHEMICAL JOURNAL},

volume = {478},

number = {6},

pages = {1199-1225},

abstract = {PI3Ks are important lipid kinases that produce phosphoinositides 

 phosphorylated in position 3 of the inositol ring. There are three 

 classes of PI3Ks: class I PI3Ks produce PIP3 at plasma membrane level. 

 Although D. melanogaster and C. elegans have only one form of class I 

 MK, vertebrates have four class I PI3Ks called isoforms despite being 

 encoded by four different genes. Hence, duplication of these genes 

 coincides with the acquisition of coordinated multi-organ development. 

 Of the class I PI3Ks, PI3K alpha and PI3K beta encoded by PIK3CA and 

 P/K3CB, are ubiquitously expressed. They present similar putative 

 protein domains and share PI(4,5)P-2 lipid substrate specificity. 

 Fifteen years after publication of their first isoform-selective 

 pharmacological inhibitors and genetically engineered mouse models 

 (GEMMs) that mimic their complete and specific pharmacological 

 inhibition, we review the knowledge gathered in relation to the 

 redundant and selective roles of PI3K alpha and Pl3K beta. Recent data 

 suggest that, further to their redundancy, they cooperate for the 

 integration of organ-specific and context-specific signal cues, to 

 orchestrate organ development, physiology, and disease. This knowledge 

 reinforces the importance of isoform-selective inhibitors in clinical 

 settings.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000631874200022,

title = {Kidney Involvement in Patients With Chronic Myelomonocytic Leukemia or 

 BCR-ABL-Negative Myeloproliferative Neoplasms},

author = {Julie Belliere and Magali Colombat and Clement Kounde and Christian Recher and David Ribes and Antoine Huart and Dominique Chauveau and Veronique Demas and Isabelle Luquet and Odile Beyne-Rauzy and Suzanne Tavitian and Stanislas Faguer},

doi = {10.1016/j.ekir.2020.12.005},

issn = {2468-0249},

year  = {2021},

date = {2021-03-01},

journal = {KIDNEY INTERNATIONAL REPORTS},

volume = {6},

number = {3},

pages = {737-745},

abstract = {Introduction: The identification of specific molecular signatures and 

 the development of new targeted drugs have changed the paradigm of 

 onco-nephrology, now allowing a multiscale approach of kidney 

 involvement related to hematologic malignancies relying on combined 

 hematologic and molecular assessments. In this study, we aimed to refine 

 the spectrum of kidney disorders associated with chronic myelomonocytic 

 leukemia (CMML) or BCR-ABL-negative myeloproliferative neoplasms (MPNs), 

 2 very rare conditions scarcely described. 

 Methods: Case series. Patients with myeloid neoplasms who were referred 

 to Toulouse University Hospital Nephrology Unit and were diagnosed with 

 acute kidney injury (AKI), chronic kidney disease (CKD), or urine 

 abnormalities were retrospectively included. Results: Eighteen patients (males n=13, CMML n=8, essential thrombocytosis [ET] n=7, polycythemia vera [PV] n=1, and myelofibrosis n=2) developed kidney disease 7.7 +/- 2 years after the 

 diagnosis of the malignancy. Twelve patients had AKI at presentation. 

 Eight patients had glomerular presentation (high-range proteinuria 33%, microscopic hematuria 56%). Kidney biopsy (n=14) showed various patterns, including pauci-immune glomerulosclerosis (n=5), extramedullary hematopoiesis (n=6), or tubular atrophy and interstitial fibrosis with polymorphic inflammation (n=8). Immunostaining of CD61 

 confirmed the infiltration of megakaryocytes within glomeruli or 

 interstitium in 5 of 8 patients. Other pictures of glomerulopathy were identified in 3 patients (IgA nephropathy n=2, AA amyloidosis n=1). 

 Massive kidney infiltration by CMML was identified in 1 patient. After a 

 mean follow-up of 2416 months, malignancy was considered as stable in 11 

 patients (61%), but 22% of patients had progressed to end-stage renal 

 failure. The remaining had persistently reduced kidney function. No 

 correlation between the malignancy and the renal presentation and 

 outcomes could be identified. 

 Conclusions: Kidney complications of CMML/MPN are heterogenous, and 

 kidney biopsy may help to identify new molecular targets to prevent the 

 development of kidney fibrosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000639412900001,

title = {Case Report: Successful Cerebral Revascularization and Cardiac 

 Transplant in a 16-Year-Old Male With Syndromic BRCC3-Related Moyamoya 

 Angiopathy},

author = {Pierrick Pyra and Jean Darcourt and Marion Aubert-Mucca and Pierre Brandicourt and Olivier Patat and Emmanuel Cheuret and Karine Brochard and Annick Sevely and Lionel Calviere and Clement Karsenty},

doi = {10.3389/fneur.2021.655303},

issn = {1664-2295},

year  = {2021},

date = {2021-03-01},

journal = {FRONTIERS IN NEUROLOGY},

volume = {12},

abstract = {Background: BRCC3/MTCP1 deletions are associated with a rare familial 

 moyamoya angiopathy with extracranial manifestations. 

 Case: We report the case of an adolescent male presenting with 

 progressive and symptomatic moyamoya angiopathy and severe dilated 

 cardiomyopathy caused by a hemizygous deletion of BRCC3/MTCP1. He was 

 treated for renovascular hypertension by left kidney homograft and right 

 nephrectomy in infancy and had other syndromic features, including 

 cryptorchidism, growth hormone deficiency, and facial dysmorphism. Due 

 to worsening of the neurological and cardiac condition, he was treated 

 by a direct superficial temporal artery to middle cerebral artery bypass 

 to enable successful cardiac transplant without cerebral damage. 

 Conclusions: BRCC3-related moyamoya is a devastating disease with severe 

 heart and brain complications. This case shows that aggressive 

 management with cerebral revascularization to allow cardiac transplant 

 is feasible and efficient despite end-stage heart failure.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000627412900015,

title = {Cytotoxic CD8(+) T cells promote granzyme B-dependent adverse 

 post-ischemic cardiac remodeling},

author = {Icia Santos-Zas and Jeremie Lemarie and Ivana Zlatanova and Marine Cachanado and Jean-Christophe Seghezzi and Hakim Benamer and Pascal Goube and Marie Vandestienne and Raphael Cohen and Maya Ezzo and Vincent Duval and Yujiao Zhang and Jin-Bo Su and Alain Bize and Lucien Sambin and Philippe Bonnin and Maxime Branchereau and Christophe Heymes and Corinne Tanchot and Jose Vilar and Clement Delacroix and Jean-Sebastien Hulot and Clement Cochain and Patrick Bruneval and Nicolas Danchin and Alain Tedgui and Ziad Mallat and Tabassome Simon and Bijan Ghaleh and Jean-Sebastien Silvestre and Hafid Ait-Oufella},

doi = {10.1038/s41467-021-21737-9},

issn = {2041-1723},

year  = {2021},

date = {2021-03-01},

journal = {NATURE COMMUNICATIONS},

volume = {12},

number = {1},

abstract = {Acute myocardial infarction is a common condition responsible for heart 

 failure and sudden death. Here, we show that following acute myocardial 

 infarction in mice, CD8(+) T lymphocytes are recruited and activated in 

 the ischemic heart tissue and release Granzyme B, leading to 

 cardiomyocyte apoptosis, adverse ventricular remodeling and 

 deterioration of myocardial function. Depletion of CD8(+) T lymphocytes 

 decreases apoptosis within the ischemic myocardium, hampers inflammatory 

 response, limits myocardial injury and improves heart function. These 

 effects are recapitulated in mice with Granzyme B-deficient CD8(+) T 

 cells. The protective effect of CD8 depletion on heart function is 

 confirmed by using a model of ischemia/reperfusion in pigs. Finally, we 

 reveal that elevated circulating levels of GRANZYME B in patients with 

 acute myocardial infarction predict increased risk of death at 1-year 

 follow-up. Our work unravels a deleterious role of CD8(+) T lymphocytes 

 following acute ischemia, and suggests potential therapeutic strategies 

 targeting pathogenic CD8(+) T lymphocytes in the setting of acute 

 myocardial infarction. Immune cells contribute to adverse remodeling 

 following myocardial infarction. Here the authors show in mice and pigs 

 that CD8(+) lymphocytes release Granzyme B in the infarcted heart 

 leading to cardiomyocyte death, enhanced inflammation and deterioration 

 of cardiac function.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000621328400005,

title = {A role for 4-hydroxy-2-nonenal in premature placental senescence in 

 preeclampsia and intrauterine growth restriction},

author = {Oriane Tasta and Audrey Swiader and Marie-Helene Grazide and Myriam Rouahi and Olivier Parant and Christophe Vayssiere and Emmanuel Bujold and Robert Salvayre and Paul Guerby and Anne Negre-Salvayre},

doi = {10.1016/j.freeradbiomed.2021.01.002},

issn = {0891-5849},

year  = {2021},

date = {2021-02-01},

journal = {FREE RADICAL BIOLOGY AND MEDICINE},

volume = {164},

pages = {303-314},

abstract = {Premature placental senescence is a hallmark of pregnancy-related 

 disorders such as intrauterine growth restriction (IUGR) and 

 preeclampsia (PE), two major cause of maternal and neonatal morbidity 

 and mortality. Oxidative stress and lipid peroxidation are involved in 

 the pathogenesis of PE and IUGR, and may play a role in placental aging. 

 In this study, we investigated whether 4-hydroxy-2-nonenal (HNE), a 

 lipid peroxidation-derived aldehyde present in preeclamptic placentas, 

 may contribute to premature senescence in placenta-related 

 complications. 

 Placentas from PE-affected women, exhibited several senescence patterns, 

 such as an increased expression of phosphorylated (serine-139) histone 

 gamma H2AX, a sensitive marker of double-stranded DNA breaks, the 

 presence of lipofuscin granules, and an accumulation of high molecular 

 weight cross-linked and ubiquitinated proteins. PE placentas showed an 

 accumulation of acetylated proteins consistent with the presence of 

 HNE-adducts on sirtuin 1 (SIRT1). Likewise, oxidative stress and 

 senescence markers together with SIRT1 modification by HNE, were 

 observed in murine placentas from mice treated with lipopolysaccharide 

 during gestation and used as models of IUGR. The addition of HNE and ONE 

 (4-oxo-2-nonenal), to cultured HTR-8/SVneo human trophoblasts activated 

 the senescence-associated- beta-galactosidase, and generated an 

 accumulation of acetylated proteins, consistent with a modification of 

 SIRT1 by HNE. 

 Altogether, these data emphasize the role of HNE and lipid 

 peroxidation-derived aldehydes in premature placental senescence in PE 

 and IUGR, and more generally in pathological pregnancies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000618208900001,

title = {Editorial: Inflammatory Cells in the Sick Heart and Adipose Tissue: 

 Novel Targets for Old and New Drugs},

author = {Laura Raimondi and Angelo Parini},

doi = {10.3389/fphys.2020.612228},

issn = {1664-042X},

year  = {2021},

date = {2021-02-01},

journal = {FRONTIERS IN PHYSIOLOGY},

volume = {11},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000623337600001,

title = {Perineal Wound Closure Following Abdominoperineal Resection and Pelvic 

 Exenteration for Cancer: A Systematic Review and Meta-Analysis},

author = {Etienne Buscail and Cindy Canivet and Jason Shourick and Elodie Chantalat and Nicolas Carrere and Jean-Pierre Duffas and Antoine Philis and Emilie Berard and Louis Buscail and Laurent Ghouti and Benoit Chaput},

doi = {10.3390/cancers13040721},

year  = {2021},

date = {2021-02-01},

journal = {CANCERS},

volume = {13},

number = {4},

abstract = {Simple Summary: Abdominoperineal resection (APR) and pelvic exenteration 

 (PE) for the treatment of cancer (mainly anal and rectal cancers) 

 require extensive pelvic resection with a high rate of postoperative 

 complications. The objective of this work was to systematically review 

 and meta-analyze the effects of vertical rectus abdominis myocutaneous 

 flap (VRAMf) and mesh closure on perineal morbidity following APR and 

 PE. The studies were distributed as follows: Group A comparing primary 

 closure (PC) and VRAMf, Group B comparing PC and mesh closure, Group C 

 comparing PC and VRAMf in PE. The meta-analysis of Groups A and B showed 

 PC to be associated with an increase in the rate of total and major 

 perineal wound complications. PC was associated with a decrease in total 

 and major perineal complications in Group C. 

 Background. Abdominoperineal resection (APR) and pelvic exenteration 

 (PE) for the treatment of cancer require extensive pelvic resection with 

 a high rate of postoperative complications. The objective of this work 

 was to systematically review and meta-analyze the effects of vertical 

 rectus abdominis myocutaneous flap (VRAMf) and mesh closure on perineal 

 morbidity following APR and PE (mainly for anal and rectal cancers). 

 Methods. We searched PubMed, Cochrane, and EMBASE for eligible studies 

 as of the year 2000. After data extraction, a meta-analysis was 

 performed to compare perineal wound morbidity. The studies were 

 distributed as follows: Group A comparing primary closure (PC) and 

 VRAMf, Group B comparing PC and mesh closure, and Group C comparing PC 

 and VRAMf in PE. Results. Our systematic review yielded 18 eligible 

 studies involving 2180 patients (1206 primary closures, 647 flap 

 closures, 327 mesh closures). The meta-analysis of Groups A and B showed 

 PC to be associated with an increase in the rate of total (Group A: OR 0.55, 95% CI 0.43-0.71; p < 0.01/Group B: OR 0.54, CI 0.17-1.68; p = 

 0.18) and major perineal wound complications (Group A: OR 0.49, 95% CI 

 0.35-0.68; p < 0.001/Group B: OR 0.38, 95% CI 0.12-1.17; p < 0.01). PC 

 was associated with a decrease in total (OR 2.46, 95% CI 1.39-4.35; p < 0.01) and major (OR 1.67, 95% CI 0.90-3.08; p = 0.1) perineal 

 complications in Group C. Conclusions. Our results confirm the 

 contribution of the VRAMf in reducing major complications in APR. 

 Similarly, biological prostheses offer an interesting alternative in 

 pelvic reconstruction. For PE, an adapted reconstruction must be 

 proposed with specialized expertise.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000623822200001,

title = {The Chemokine Receptor CCR3 Is Potentially Involved in the Homing of 

 Prostate Cancer Cells to Bone: Implication of Bone-Marrow Adipocytes},

author = {Adrien Guerard and Victor Laurent and Gaelle Fromont and David Esteve and Julia Gilhodes and Edith Bonnelye and Sophie Le Gonidec and Philippe Valet and Bernard Malavaud and Nicolas Reina and Camille Attane and Catherine Muller},

doi = {10.3390/ijms22041994},

year  = {2021},

date = {2021-02-01},

journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},

volume = {22},

number = {4},

abstract = {Bone metastasis remains the most frequent and the deadliest complication 

 of prostate cancer (PCa). Mechanisms leading to the homing of tumor 

 cells to bone remain poorly characterized. Role of chemokines in 

 providing navigational cues to migrating cancer cells bearing specific 

 receptors is well established. Bone is an adipocyte-rich organ since 50 

 to 70% of the adult bone marrow (BM) volume comprise bone marrow 

 adipocytes (BM-Ads), which are likely to produce chemokines within the 

 bone microenvironment. Using in vitro migration assays, we demonstrated 

 that soluble factors released by human primary BM-Ads are able to 

 support the directed migration of PCa cells in a CCR3-dependent manner. 

 In addition, we showed that CCL7, a chemokine previously involved in the 

 CCR3-dependent migration of PCa cells outside of the prostate gland, is 

 released by human BM-Ads. These effects are amplified by obesity and 

 ageing, two clinical conditions known to promote aggressive and 

 metastatic PCa. In human tumors, we found an enrichment of CCR3 in bone 

 metastasis vs. primary tumors at mRNA levels using Oncomine microarray 

 database. In addition, immunohistochemistry experiments demonstrated 

 overexpression of CCR3 in bone versus visceral metastases. These results 

 underline the potential importance of BM-Ads in the bone metastatic 

 process and imply a CCR3/CCL7 axis whose pharmacological interest needs 

 to be evaluated.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000623848700001,

title = {Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: 

 From Physiology to Medical Implications},

author = {Emmanuelle Noirrit-Esclassan and Marie-Cecile Valera and Florence Tremollieres and Jean-Francois Arnal and Francoise Lenfant and Coralie Fontaine and Alexia Vinel},

doi = {10.3390/ijms22041568},

year  = {2021},

date = {2021-02-01},

journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},

volume = {22},

number = {4},

abstract = {Bone is a multi-skilled tissue, protecting major organs, regulating 

 calcium phosphate balance and producing hormones. Its development during 

 childhood determines height and stature as well as resistance against 

 fracture in advanced age. Estrogens are key regulators of bone turnover 

 in both females and males. These hormones play a major role in 

 longitudinal and width growth throughout puberty as well as in the 

 regulation of bone turnover. In women, estrogen deficiency is one of the 

 major causes of postmenopausal osteoporosis. In this review, we will 

 summarize the main clinical and experimental studies reporting the 

 effects of estrogens not only in females but also in males, during 

 different life stages. Effects of estrogens on bone involve either 

 Estrogen Receptor (ER)alpha or ER beta depending on the type of bone 

 (femur, vertebrae, tibia, mandible), the compartment (trabecular or 

 cortical), cell types involved (osteoclasts, osteoblasts and osteocytes) 

 and sex. Finally, we will discuss new ongoing strategies to increase the 

 benefit/risk ratio of the hormonal treatment of menopause.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000601336400013,

title = {TBS in early postmenopausal women with severe vertebral osteoporosis},

author = {Jean-Michel Pouilles and Anna Gosset and Alice Breteau and Florence Anne Tremollieres},

doi = {10.1016/j.bone.2020.115698},

issn = {8756-3282},

year  = {2021},

date = {2021-01-01},

journal = {BONE},

volume = {142},

abstract = {Introduction/background: Severe vertebral osteoporosis is a rare 

 condition in early postmenopausal women. We seek to determine whether 

 Trabecular Bone Score (TBS), which is a new bone texture measurement, 

 could be of additional value in evaluating trabecular bone properties in 

 this population. 

 Methodology: Lumbar spine (LS) and femoral neck (FN) bone mineral 

 densities (BMDs) and TBS were measured in 105 early postmenopausal women 

 (group 1: ``cases'', mean age: 53.1 +/- 2.6 yrs.) with severe vertebral osteoporosis defined as a vertebral BMD T-score <= 3, as well 

 as in 105 healthy postmenopausal women matched for age (group 2) and 105 

 older osteoporotic women matched for vertebral BMD (group 3, mean age: 

 63.9 +/- 4 yrs.). None of the women had a secondary cause for 

 osteoporosis. Correlations between TBS values and BMD were calculated 

 after controlling for clinical characteristics. 

 Results: The women in group 1 (cases) were significantly smaller and 

 thinner and had a history of more fractures than the age-matched 

 controls (p < 0.05). Mean LS and FN BMD values were significantly lower 

 in the cases than in the age-matched controls (0.770 +/- 0.05 vs 1.106 

 +/- 0.11 g/cm(2) and 0.700 +/- 0.07 vs 0.872 +/- 0.12 g/cm(2), for LS 

 and FN, respectively; p < 0.001). The mean TBS value was also 

 significantly lower in the cases than in the age matched controls (1.24 

 +/- 0.08 vs 1.37 +/- 0.07, p < 0.001) but significantly higher than in 

 the older osteoporotic controls (1.20 +/- 0.07, p < 0.05). After 

 adjustment for vertebral BMD, the difference in TBS values between the 

 cases and the age-matched controls was no longer significant although it 

 remained significantly higher than in the older osteoporotic controls. 

 This would suggest that in group 1, osteoporosis is rather the 

 consequence of a low peak bone mass than of further bone degradation 

 while the greater decrease in TBS value in elderly osteoporotic controls 

 is more likely to reflect additional damage in bone microarchitecture 

 associated with aging. In a multivariate analysis including age, vertebral and femoral neck BMD, height and weight (R-2 = 0.60, p < 

 0.0001), TBS was found to be negatively and independently associated with age (r =-0.31 p < 0.0001) and height (r =-0.20 p < 0.001). The FRAX 

 score was significantly higher in group 1 and group 3 women than in the 

 healthy control women (group 2). There were no changes in the results 

 after adjustment for TBS. 

 Conclusions: Women presenting with severe vertebral osteoporosis at the 

 beginning of menopause have TBS values that are, first and foremost, 

 proportional to their BMD. Whether this indicates that osteoporosis in 

 this population is the consequence of a low peak bone mass remains to be 

 determined and further studies are required. Nevertheless, the value of 

 measuring TBS in addition to BMD appears to be relatively negligible in 

 early postmenopausal women with severe vertebral osteoporosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000613698700004,

title = {Estetrol prevents Western diet-induced obesity and atheroma 

 independently of hepatic estrogen receptor alpha},

author = {Melissa Buscato and Morgane Davezac and Rana Zahreddine and Marine Adlanmerini and Raphael Metivier and Marianne Fillet and Gael Cobraiville and Cedric Moro and Jean-Michel Foidart and Francoise Lenfant and Pierre Gourdy and Jean-Francois Arnal and Coralie Fontaine},

doi = {10.1152/ajpendo.00211.2020},

issn = {0193-1849},

year  = {2021},

date = {2021-01-01},

journal = {AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM},

volume = {320},

number = {1},

pages = {E19-E29},

abstract = {Estetrol (E4), a natural estrogen synthesized by the human fetal liver, 

 is currently evaluated in phase III clinical studies as a new menopause 

 hormone therapy. Indeed, E4 significantly improves vasomotor and 

 genito-urinary menopausal symptoms and prevents bone demineralization. 

 Compared with other estrogens, E4 was found to have limited effects on 

 coagulation factors in the liver of women allowing to expect less 

 thrombotic events. To fully delineate its clinical potential, the aim of 

 this study was to assess the effect of E4 on metabolic disorders. Here, 

 we studied the pathophysiological consequences of a Western diet (42% 

 kcal fat, 0.2% cholesterol) in ovariectomized female mice under chronic 

 E4 treatment. We showed that E4 reduces body weight gain and improves 

 glucose tolerance in both C57Bl/6 and LDLR-/- mice. To evaluate the role 

 of hepatic estrogen receptor (ER) alpha in the preventive effect of E4 

 against obesity and associated disorders such as atherosclerosis and 

 steatosis, mice har boring a hepatocyte-specific ER alpha deletion 

 (LERKO) were crossed with LDLR-/- mice. Our results demonstrated that, 

 whereas liver ER alpha is dispensable for the E4 beneficial actions on 

 obesity and atheroma, it is necessary to prevent steatosis in mice. 

 Overall, these findings suggest that E4 could prevent metabolic, 

 hepatic, and vascular disorders occurring at menopause, extending the 

 potential medical interest of this natural estrogen as a new hormonal 

 treatment. 

 NEW & NOTEWORTHY Estetrol prevents obesity, steatosis, and 

 atherosclerosis in mice fed a Western diet. Hepatic ERa is necessary for 

 the prevention of steatosis, but not of obesity and atherosclerosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000623251500002,

title = {Low-dose Btk inhibitors: an `aspirin' of tomorrow?},

author = {Bernard Payrastre and Agnes Ribes},

doi = {10.3324/haematol.2020.265173},

issn = {0390-6078},

year  = {2021},

date = {2021-01-01},

journal = {HAEMATOLOGICA},

volume = {106},

number = {1},

pages = {2-4},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000608211500002,

title = {A study of patients' quality of life more than 5 years after trauma: a 

 prospective follow-up},

author = {Fanny Vardon-Bounes and Romain Gracia and Timothee Abaziou and Laure Crognier and Thierry Seguin and Francois Labaste and Thomas Geeraerts and Bernard Georges and Jean-Marie Conil and Vincent Minville},

doi = {10.1186/s12955-020-01652-1},

year  = {2021},

date = {2021-01-01},

journal = {HEALTH AND QUALITY OF LIFE OUTCOMES},

volume = {19},

number = {1},

abstract = {Background: The long-term fate of severely injured patients in terms of 

 their quality of life is not well known. Our aim was to assess the 

 quality of life of patients who have suffered moderate to severe trauma 

 and to identify primary factors of long-term quality of life impairment. 

 Methods: A prospective monocentric study conducted on a number of 

 patients who were victims of moderate to severe injuries during the year 

 2012. Patients were selected based on an Injury Severity Score (ISS) 

 more than or equal to 9. Quality of life was assessed by the MOS SF-36 

 and NHP scores as a primary evaluation criterion. The secondary 

 evaluation criteria were the determination of the socio-economic impact 

 on quality of life and the identification of factors associated with 

 disability. 

 Results: Two hundred and eight patients were contacted by e-mail or 

 telephone. Fifty-five patients participated in this study (with a 

 participation level of 26.4%), including 78.2% men, with a median age 

 of 46. Significant alterations in quality of life were observed with the 

 NHP and MOS SF-36 scale, including physical and psychological 

 components. This resulted in a major socio-economic impact as 26% of the patients could not resume their professional activities (n = 10), 

 20% required retraining in other lines of work, and 36.4% had a disability status. The study showed that scores <= 85 on the physical 

 functioning variable of the MOS SF 36 scale was associated with 

 disability. 

 Conclusion: More than five years after a moderate to severe injury, 

 patients' quality of life was significantly impacted, resulting in 

 significant socio-economic consequences. Disability secondary to major trauma seems to be associated with a score <= 85 on the physical 

 functioning dimension of the MOS SF-36 scale. This study raises the 

 question of whether or not early rehabilitation programs should be 

 implemented in order to limit the long-term impact of major trauma.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000611511500003,

title = {Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant 

 acute myeloid leukemia cells},

author = {Clement Larrue and Nathan Guiraud and Pierre-Luc Mouchel and Marine Dubois and Thomas Farge and Mathilde Gotanegre and Claudie Bosc and Estelle Saland and Marie-Laure Nicolau-Travers and Marie Sabatier and Nizar Serhan and Ambrine Sahal and Emeline Boet and Sarah Mouche and Quentin Heydt and Nesrine Aroua and Lucille Stuani and Tony Kaoma and Linus Angenendt and Jan-Henrik Mikesch and Christoph Schliemann and Francois Vergez and Jerome Tamburini and Christian Recher and Jean-Emmanuel Sarry},

doi = {10.1038/s41467-020-20717-9},

issn = {2041-1723},

year  = {2021},

date = {2021-01-01},

journal = {NATURE COMMUNICATIONS},

volume = {12},

number = {1},

abstract = {Drug tolerant/resistant leukemic stem cell (LSC) subpopulations may 

 explain frequent relapses in acute myeloid leukemia (AML), suggesting 

 that these relapse-initiating cells (RICs) persistent after chemotherapy 

 represent bona fide targets to prevent drug resistance and relapse. We 

 uncover that calcitonin receptor-like receptor (CALCRL) is expressed in 

 RICs, and that the overexpression of CALCRL and/or of its ligand 

 adrenomedullin (ADM), and not CGRP, correlates to adverse outcome in 

 AML. CALCRL knockdown impairs leukemic growth, decreases LSC frequency, 

 and sensitizes to cytarabine in patient-derived xenograft models. 

 Mechanistically, the ADM-CALCRL axis drives cell cycle, DNA repair, and 

 mitochondrial OxPHOS function of AML blasts dependent on E2F1 and BCL2. 

 Finally, CALCRL depletion reduces LSC frequency of RICs 

 post-chemotherapy in vivo. In summary, our data highlight a critical 

 role of ADM-CALCRL in post-chemotherapy persistence of these cells, and 

 disclose a promising therapeutic target to prevent relapse in AML. 

 Leukemic stem cells which are resistant to chemotherapy are proposed as 

 relapse-initiating cells (RICs). Here, the authors show that targeting 

 the adrenomedullin-calcitonin receptor-like receptor decreases RICs 

 frequency improving chemotherapy response in AML preclinical models.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000648062400001,

title = {Urinary peptides in heart failure: a link to molecular pathophysiology},

author = {Tianlin He and Michaela Mischak and Andrew L Clark and Ross T Campbell and Christian Delles and Javier Diez and Gerasimos Filippatos and Alexandre Mebazaa and John J V McMurray and Arantxa Gonzalez and Julia Raad and Rafael Stroggilos and Helle S Bosselmann and Archie Campbell and Shona M Kerr and Colette E Jackson and Jane A Cannon and Morten Schou and Nicolas Girerd and Patrick Rossignol and Alex McConnachie and Kasper Rossing and Joost P Schanstra and Faiez Zannad and Antonia Vlahou and William Mullen and Vera Jankowski and Harald Mischak and Zhenyu Zhang and Jan A Staessen and Agnieszka Latosinska},

doi = {10.1002/ejhf.2195, Early Access Date = MAY 2021},

issn = {1388-9842},

journal = {EUROPEAN JOURNAL OF HEART FAILURE},

abstract = {Aims Heart failure (HF) is a major public health concern worldwide. The 

 diversity of HF makes it challenging to decipher the underlying complex 

 pathological processes using single biomarkers. We examined the 

 association between urinary peptides and HF with reduced (HFrEF), 

 mid-range (HFmrEF) and preserved (HFpEF) ejection fraction, defined 

 based on the European Society of Cardiology guidelines, and the links 

 between these peptide biomarkers and molecular pathophysiology. 

 Methods and results Analysable data from 5608 participants were 

 available in the Human Urinary Proteome database. The urinary peptide 

 profiles from participants diagnosed with HFrEF, HFmrEF, HFpEF and 

 controls matched for sex, age, estimated glomerular filtration rate, 

 systolic and diastolic blood pressure, diabetes and hypertension were 

 compared applying the Mann-Whitney test, followed by correction for 

 multiple testing. Unsupervised learning algorithms were applied to 

 investigate groups of similar urinary profiles. A total of 577 urinary 

 peptides significantly associated with HF were sequenced, 447 of which 

 (77%) were collagen fragments. In silico analysis suggested that 

 urinary biomarker abnormalities in HF principally reflect changes in 

 collagen turnover and immune response, both associated with fibrosis. 

 Unsupervised clustering separated study participants into two clusters, 

 with 83% of non-HF controls allocated to cluster 1, while 65% of 

 patients with HF were allocated to cluster 2 (P < 0.0001). No separation 

 based on HF subtype was detectable. 

 Conclusions Heart failure, irrespective of ejection fraction subtype, 

 was associated with differences in abundance of urinary peptides 

 reflecting collagen turnover and inflammation. These peptides should be 

 studied as tools in early detection, prognostication, and prediction of 

 therapeutic response.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000620222900001,

title = {Transcatheter aortic valve thrombosis: Data from a French multicenter 

 cohort analysis},

author = {Thomas Mouyen and Thibaut Manigold and Jean-Philippe Collet and Eric Durand and Christophe Barbey and Thibault Lhermusier and Didier Tchetche and Thomas Chollet and Aurelien Mulliez and Pascal Motreff and Nicolas Combaret and Geraud Souteyrand},

doi = {10.1002/ccd.29555, Early Access Date = FEB 2021},

issn = {1522-1946},

journal = {CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS},

abstract = {Objectives To evaluate the effectiveness of anticoagulant therapies in 

 patients with clinical transcatheter heart valve (THV) thrombosis, to 

 describe complications, and to assess their risk profile was the 

 objectives. 

 Background Little research has been conducted on clinical THV 

 thrombosis. 

 Methods Patients with clinical THV thrombosis were identified based on 

 greater than 50% increased transvalvular gradient on transthoracic 

 echocardiogram confirmed by 4-dimensional computed tomography, 

 transesophageal echocardiogram, or regression with anticoagulant 

 therapy. A cohort free from thrombosis for more than 1,100 days 

 postprocedure was used for comparison. 

 Results Fifty-four patients with clinical THV thrombosis were 

 identified. Most subjects (98.1%) received anticoagulant therapy which was effective (>= 50% reduction in transvalvular gradient or return to 

 postprocedure value) in 96%. The rate of serious hemodynamic or embolic 

 complications in the thrombosis population was 31.5%. A multivariate 

 analysis of subjects with and without thrombosis indicated a 

 significantly increased risk of thrombosis from preexisting 

 thrombocytopenia (odds ratio [OR] 9.96), absence of predilatation (OR = 5.67), renal insufficiency (OR = 4.84), and >10 mmHg mean transvalvular gradient postprocedure (OR = 3.36). No recurrence of 

 thrombosis was identified during on average 685 days follow-up. 

 Conclusions These data, from one of the largest cohorts with clinical 

 THV thrombosis confirm anticoagulants appear effective. The rate of 

 serious associated complications was high. The findings underline the 

 importance of recognizing risk factors for thrombosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000656817500001,

title = {Impact of menopausal status on kidney adaptation after unilateral 

 nephrectomy for kidney donation in women},

author = {Pierre-Yves Charles and Marion Vallet and Renaud De la Faille and Pierre Merville and Severine Lagarde and Nicolas Grenier and Claire Lebely and Benoit Lepage and Julien Allard and Nassim Kamar and Ivan Tack},

doi = {10.1007/s40620-021-01067-1, Early Access Date = JUN 2021},

issn = {1121-8428},

journal = {JOURNAL OF NEPHROLOGY},

abstract = {Introduction Although living kidney donation is not a high-risk surgery, 

 there is still a need to identify situations at risk of kidney disease 

 after uninephrectomy. Estrogens exhibit a protective role against 

 various nephropathies. The aim of this study was to assess renal 

 adaptation following nephrectomy according to menopausal status in 

 women. 

 Methods A prospective bicentric study including living women donors 

 measured glomerular filtration rate (GFR) (inulin or Cr51--EDTA 

 clearances) and kidney volume (using CT-scan and 3-dimensional 

 reconstruction), before and after 1-year post-uninephrectomy. Renal 

 adaptation was compared according to menopausal status. 

 Results Sixteen non-menopausal women and 18 menopausal women were 

 included. One year following uninephrectomy, the mean decrease in GFR 

 (global population) was - 32 +/- 12 ml/min/1.73 m(2), and the mean 

 increase in remnant kidney volume was + 32 +/- 13 cm(3)/1.73 m(2). No 

 significant difference was observed between the two groups for both the 

 decrease in GFR (-32.9 +/- 13.3 in non-menopausal vs - 31.5 +/- 9.9 in menopausal, ml/min/1.73 m(2)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000664749300001,

title = {Cytokine storm induced by a PD1 inhibitor in a renal transplant patient},

author = {Arnaud Del Bello and Alexia G Zakaroff and Nicolas Meyer and Audrey Delas and Stanislas Faguer and Nassim Kamar and Julie Belliere},

doi = {10.1111/ajt.16589, Early Access Date = JUN 2021},

issn = {1600-6135},

journal = {AMERICAN JOURNAL OF TRANSPLANTATION},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{ISI:000657602300001,

title = {Toothbrushing in children with autism spectrum disorders: qualitative 

 analysis of parental difficulties and solutions in France},

author = {M Teste and A Broutin and M Marty and M C Valera and F Soares Cunha and E Noirrit-Esclassan},

doi = {10.1007/s40368-021-00640-3, Early Access Date = JUN 2021},

issn = {1818-6300},

journal = {EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY},

abstract = {Purpose The oral care of a child with autism spectrum disorders (ASD) is 

 a challenge, not only for dentists, but also for parents. The objective 

 of this study was to evaluate the difficulties encountered by parents in 

 maintaining oral hygiene in autistic children and the solutions they 

 found to facilitate this daily act. 

 Methods A questionnaire with closed and open questions about 

 characteristics of the child and oral health at home, conducted via 

 Google Form, was sent to French families through 301 associations of 

 parents with autistic children. For the quantitative analysis, logistic 

 regression was used. The open answers were analysed by theme. 

 Results This study included 756 offspring aged 14.4 (+/- 8.1) years. 

 Girls were 1.7 (95% CI: 1.1-2.8) times more likely to have 

 toothbrushing difficulty than boys. Nonverbal patients (OR:3.2; 95% CI: 

 2.2-4.9), autistic patients (OR:2.8; 95% CI: 1.4-5.2), patients using 

 pictograms (OR:1.6; 95% CI: 1.1-2.4), and younger children (OR:0.9; 

 95% CI: 0.9-0.9) were significantly more likely to encounter 

 difficulties in tolerating toothbrushing. The qualitative analysis 

 showed that parents used three main ways to facilitate toothbrushing: 

 planning, modelling and making it enjoyable. Seventy-nine percent of 

 parents did not feel sufficiently informed about the different oral 

 hygiene prevention tools and techniques for their ASD children and would 

 like to be educated in the daily management of oral hygiene. 

 Conclusion The role of parents remains essential and professionals 

 should work in collaboration with them.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}