Membres de l'équipe


MARTINEZ Laurent (DR2)

05 31 22 41 47






05 31 22 40 82





GAYRAL Stephanie (CRCN)



CABOU Cendrine (MCU)


PERRET Bertrand (PU-PH)


GENOUX Annelise (MCU/PH)

05 31 22 40 82




DUPARC Thibaut (Post-doc)

05 31 22 40 82


GORE Emilia (Post-doc)


WAHART Amandine (Post-doc)



BEUZELIN Diane (Lifesearch)

05 31 22 41 44


FAY Alexis (IE)


MERIAN Jules (Doctorant)

05 31 22 40 82


MALET Nicole (TN)


COMBES Guillaume (AI)


GRZESIAK Lucile (Doctorant)



SARTHOU Marie-K (Doctorant)




GODIN Etienne (M2R)

32424189Serum level of High-density lipoprotein particles are independently associated with long-term prognosis in patients with coronary artery disease: The GENES studyDuparc T, Ruidavets JB, Genoux A, Ingueneau C, Najib S, Ferrieres J, Perret B*, Martinez L.O*. Co-last.2020Sci Rep.
33469068Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case-control study.Costa C, Ruidavet JB, Bongard, Perret B, Repetto E, Stathopoulou MG, Serra F, Benahmed M, Mauduit C, Grandjean V, Ferrières J, Martinez LO*, Trabucchi M*. Co-last.2020Sci Rep.
32881754Is it time to reconcile HDL with cardiovascular diseases and beyond? An update on a paradigm shift.Martinez LO, Ingueneau C, Genoux A.2020Curr Opin Lipidol.
31106375Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response Lupieri A, Smirnova NF, Solinhac R, Malet N, Benamar M, Saoudi A, Santos-Zas I, Zeboudj L, Ait-Oufella H, Hirsch E, Ohayon P, Lhermusier T, Carrié D, Arnal JF, Ramel D, Gayral S, Laffargue M.2020Cardiovasc. Res
31941925PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stressBoukhalfa A, Nascimbeni AC, Ramel D, Dupont N, Hirsch E, Gayral S, Laffargue M, Codogno P, Morel E.2020Nat. commun.
32482794A non-catalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage Lupieri A, Blaise R, Ghigo A, Smirnova N, Sarthou MK, Malet N, Limon I, Vincent P, Hirsch E, Gayral S, Ramel D, Laffargue M.2020J. Cell. Sci
32887042A reference measurement of circulating ATPase inhibitory factor 1 (IF1) in humans by LC-MS/MS: Comparison with conventional ELISA.Genoux A, Duparc T, Ruidavets JB, Ingueneau C, Najib S, Ferrières J, Perret B, Croyal M, Martinez LO.2020Talanta
32987194Treatment with PCSK9 inhibitors induces a more anti-atherogenic HDL lipid profile in patients at high cardiovascular risk.Ingueneau C, Hollstein T, Grenkowitz T, Ruidavets JB, Kassner U, Duparc T, Combes G, Perret B, Genoux A, Schumann F, Bobbert T, Steinhagen-Thiessen E, Martinez LO.2020Vascul Pharmacol.
30821416Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation.Cabou C, Honorato P, Briceño L, Ghezali L, Duparc T, León M, Combes G, Frayssinhes L, Fournel A, Abot A, Masri B,..., Knauf C, González M, Radojkovic C*, Martinez LO*. *Co-last2019Acta Physiol (Oxf).
30600215Common p2y13 polymorphisms are associated with plasma inhibitory factor 1 and lipoprotein(a) concentrations, heart rate and body fat mass: The GENES study.Verdier C, Ruidavets JB, Genoux A, Combes G, Bongard V, Taraszkiewicz D, Galinier M, Elbaz M, Ferrières J, Martinez LO*, Perret B*. *Co-last authors2019Arch Cardiovasc Dis.
31460789Liraglutide improves hepatic steatosis and metabolic dysfunctions in a 3-week dietary mouse model of non-alcoholic steatohepatitis.Duparc T, Briand F, Trenteseaux C, Mérian J, Combes G, Najib S, Sulpice T, L.O. Martinez.2019Am J Physiol Gastrointest
31824304Immune and Smooth Muscle Cells Interactions in Atherosclerosis: How to Target a Breaking Bad Dialogue? Ramel D, Gayral S, Sarthou MK, Augé N, Nègre-Salvayre A, Laffargue M.2019Front Pharmacol.
29523150Characterization of immortalized human dermal microvascular endothelial cells (HMEC-1) for the study of HDL functionality.Muñoz-Vega M, Massó F, Páez A, Carreón E, Cabrera HA, Fragoso JM, Pérez-Hernández N, Martinez LO, Najib S, Vargas G, Pérez-Méndez Ó2018Lipids Health Dis.
27892954A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, ..., Aalvink S, Martinez LO, Dumas ME, ..., Belzer C, de Vos WM, Cani PD.2017Nat Med.
28143705Non-autonomous role of Cdc42 in cell-cell communication during collective migrationColombié N, Choesmel-Cadamuro V, Series J, Emery G, Wang X, Ramel D.2017Dev Biol
28578353PI3Kβ Plays a Key Role in Apolipoprotein A-I-Induced Endothelial Cell Proliferation Through Activation of the Ecto-F1-ATPase/P2Y1 Receptors.Castaing-Berthou A, Malet N, Radojkovic C, Cabou C, Gayral S, Martinez LO*, Laffargue M*. *Co-last authors2017Cell Physiol Biochem.
28504211Ectopic adenine nucleotide translocase activity controls extracellular ADP levels and regulates the F1-ATPase-mediated HDL endocytosis pathway on hepatocytes.Cardouat G, Duparc T, Fried S, Perret B, Najib S*, Martinez LO*. *Co-last authors2017Biochim Biophys Acta.
28504983Serum inhibitory factor 1, high-density lipoprotein and cardiovascular diseases.Martinez LO, Genoux A, Ferrières J, Duparc T, Perret B.2017Curr Opin Lipidol.
28625343Short-term cooling increases serum triglycerides and small high-density lipoprotein levels in humans.Hoeke G, Nahon KJ, Bakker LEH, Norkauer SSC, Dinnes DLM, Kockx M, Lichtenstein L, Drettwan D, Reifel-Miller A, Coskun T, Pagel P, Romijn FPHTM, Cobbaert CM, Jazet IM, Martinez LO, Kritharides L et al.2017J Clin Lipidol.
28729453PI3K and Calcium Signaling in Cardiovascular Disease.Ghigo A, Laffargue M, Li M, Hirsch E.2017Circ res.
28980871Small GTPases orchestrate cell-cell communication during collective cell movement.Combedazou A, Gayral S, Colombié N, Fougerat A, Laffargue M, Ramel D.2017Small GTPases
27553421Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES Study.Genoux A, Lichtenstein L, Ferrières J, Duparc T, Bongard V, Vervueren PL, Combes G, Taraszkiewicz D, Elbaz M, Galinier M, Nassar B, Ruidavets JB, Perret B*, Martinez LO*. *Co-last authors2016BMC Med.
26449324RNY-derived small RNAs as a signature of coronary artery disease.Repetto E, Lichtenstein L, Hizir Z, Tekaya N, Benahmed M, Ruidavets JB, Zaragosi LE, Perret B, Bouchareychas L, Genoux A, Lotte R, Ruimy R, Ferrières J, Barbry P, Martinez LO, Trabucchi M. 2015BMC Med.
25770145Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport.Lichtenstein L, Serhan N, Espinosa-Delgado S, Fabre A, Annema W, Tietge UJ, Robaye B, Boeynaems JM, Laffargue M, Perret B, Martinez LO.2015Cardiovasc Res.
25445031Apolipoprotein A-I enhances proliferation of human endothelial progenitor cells and promotes angiogenesis through the cell surface ATP synthase.González-Pecchi V, Valdés S, Pons V, Honorato P, Martinez LO, Lamperti L, Aguayo C, Radojkovic C.2015Microvasc Res.
25437896Ecto-F1-ATPase/P2Y pathways in metabolic and vascular functions of high density lipoproteins.Martinez LO, Najib S, Perret B, Cabou C, Lichtenstein L.2015Atherosclerosis
26100075PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E.2015Nat Commun
26316608The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells.Smirnova N, Fontaine C, Buscato M, Lupieri A, Vinel A, Valera MC, Guillaume M, Malet N, Foidart JM, Raymond-Letron I, Lenfant F, Gourdy P, Katzenellenbogen B, Katzenellenbogen J, Laffargue M, Arnal JF2015Circ res.
26238239PI3K signaling in arterial diseases: Non redundant functions of the PI3K isoforms.Lupieri A, Smirnova N, Malet N, Gayral S, Laffargue M.2015Adv Biol Regul.
25109333Progastrin a new pro-angiogenic factor in colorectal cancer.Najib S, Kowalski-Chauvel A, Do C, Roche S, Cohen-Jonathan-Moyal E, Seva C.2015Oncogene.
25073791Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M.2014J Exp Med.
24357053Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway.Gayral S, Garnotel R, Castaing-Berthou A, Blaise S, Fougerat A, Berge E, Montheil A, Malet N, Wymann MP, Maurice P, Debelle L, Martiny L, Martinez LO, Pshezhetsky AV, Duca L, Laffargue M.2014Cardiovasc Res.
24030815Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake.Pons V, Serhan N, Gayral S, Malaval C, Nauze M, Malet N, Laffargue M, Galés C, Martinez LO.2014Cell Mol Life Sci.