Team members

MARTINEZ
Laurent
(DR2)

MARTINEZ Laurent (DR2)

laurent.martinez@inserm.fr

05 31 22 41 47

LAFFARGUE
Muriel
(DR2)

LAFFARGUE Muriel (DR2)

muriel.laffargue@inserm.fr

GAYRAL
Stephanie
(CR1)

GAYRAL Stephanie (CR1)

stephanie.gayral@iserm.fr

NAJIB
Souad
(CR1)

NAJIB Souad (CR1)

RAMEL
Damien
(CR2)

RAMEL Damien (CR2)

PERRET
Bertrand
(PU-PH)

PERRET Bertrand (PU-PH)

GENOUX
Annelise
(MCU/PH)

GENOUX Annelise (MCU/PH)

annelise.genoux@inserm.fr

05 31 22 40 82

CABOU
Cendrine
(MCU)

CABOU Cendrine (MCU)

VERDIER
Celine
(PH)

VERDIER Celine (PH)

DUPARC
Thibaut
(Post-doc)

DUPARC Thibaut (Post-doc)

FOUGERAT
Anne
(Post-doc)

FOUGERAT Anne (Post-doc)

SOLINHAC
Romain
(Post doc)

SOLINHAC Romain (Post doc)

mouin.nasr@inserm.fr

RAGAB
Ashraf
(IE)

RAGAB Ashraf (IE)

COMBES
Guillaume
(AI)

COMBES Guillaume (AI)

michel.nauze@inserm.fr

MALET
Nicole
(TR)

MALET Nicole (TR)

nicole.malet@inserm.fr

ANESIA
Rodica
(AI)

ANESIA Rodica (AI)

05 31 22 41 44

FRIED
Steven
(Doctorant)

FRIED Steven (Doctorant)

steven.fried@inserm.fr

05 31 22 40 82

NASR
Mouin
(Doctorant)

NASR Mouin (Doctorant)

PMIDTitleAuthorsYearJournal
28143705Non-autonomous role of Cdc42 in cell-cell communication during collective migrationColombié N, Choesmel-Cadamuro V, Series J, Emery G, Wang X, Ramel D.2017Dev Biol
28578353PI3Kβ Plays a Key Role in Apolipoprotein A-I-Induced Endothelial Cell Proliferation Through Activation of the Ecto-F1-ATPase/P2Y1 Receptors.Castaing-Berthou A, Malet N, Radojkovic C, Cabou C, Gayral S, Martinez LO, Laffargue M.2017Cell Physiol Biochem.
28504211Ectopic adenine nucleotide translocase activity controls extracellular ADP levels and regulates the F1-ATPase-mediated HDL endocytosis pathway on hepatocytes.Cardouat G, Duparc T, Fried S, Perret B, Najib S, Martinez LO.2017Biochim Biophys Acta.
28504983Serum inhibitory factor 1, high-density lipoprotein and cardiovascular diseases.Martinez LO, Genoux A, Ferrières J, Duparc T, Perret B.2017Curr Opin Lipidol.
28625343Short-term cooling increases serum triglycerides and small high-density lipoprotein levels in humans.Hoeke G, Nahon KJ, Bakker LEH, Norkauer SSC, Dinnes DLM, Kockx M, Lichtenstein L, Drettwan D, Reifel-Miller A, Coskun T, Pagel P, Romijn FPHTM, Cobbaert CM, Jazet IM, Martinez LO, Kritharides L, Berb&2017J Clin Lipidol.
28729453PI3K and Calcium Signaling in Cardiovascular Disease.Ghigo A, Laffargue M, Li M, Hirsch E.2017Circ res.
28980871Small GTPases orchestrate cell-cell communication during collective cell movement.Combedazou A, Gayral S, Colombié N, Fougerat A, Laffargue M, Ramel D.2017Small GTPases
27892954A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, ..., Aalvink S, Martinez LO, Dumas ME, ..., Belzer C, de Vos WM, Cani PD.2016Nat Med.
27553421Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES Study.Genoux A, Lichtenstein L, Ferrières J, Duparc T, Bongard V, Vervueren PL, Combes G, Taraszkiewicz D, Elbaz M, Galinier M, Nassar B, Ruidavets JB, Perret B, Martinez LO.2016BMC Med.
26449324RNY-derived small RNAs as a signature of coronary artery disease.Repetto E, Lichtenstein L, Hizir Z, Tekaya N, Benahmed M, Ruidavets JB, Zaragosi LE, Perret B, Bouchareychas L, Genoux A, Lotte R, Ruimy R, Ferrières J, Barbry P, Martinez LO, Trabucchi M. 2015BMC Med.
25770145Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport.Lichtenstein L, Serhan N, Espinosa-Delgado S, Fabre A, Annema W, Tietge UJ, Robaye B, Boeynaems JM, Laffargue M, Perret B, Martinez LO.2015Cardiovasc Res.
25445031Apolipoprotein A-I enhances proliferation of human endothelial progenitor cells and promotes angiogenesis through the cell surface ATP synthase.González-Pecchi V, Valdés S, Pons V, Honorato P, Martinez LO, Lamperti L, Aguayo C, Radojkovic C.2015Microvasc Res.
25437896Ecto-F1-ATPase/P2Y pathways in metabolic and vascular functions of high density lipoproteins.Martinez LO, Najib S, Perret B, Cabou C, Lichtenstein L.2015Atherosclerosis
26316608The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells.Smirnova NF, Fontaine C, Buscato M, Lupieri A, Vinel A, Valera MC, Guillaume M, Malet N, Foidart JM, Raymond-Letron I, Lenfant F, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Laffargue M, Arnal2015Circ res.
26238239PI3K signaling in arterial diseases: Non redundant functions of the PI3K isoforms.Lupieri A, Smirnova N, Malet N, Gayral S, Laffargue M.2015Adv Biol Regul.
26100075PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E.2015Nat Commun.
25613820Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet.Abderrazak A, Couchie D, Mahmood DF, Elhage R, Vindis C, Laffargue M, Matéo V, Büchele B, Ayala MR, El Gaafary M, Syrovets T, Slimane MN, Friguet B, Fulop T, Simmet T, El Hadri K, Rouis M.2015Circulation
25073791Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M.2014J Exp Med.
24357053Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway.Gayral S, Garnotel R, Castaing-Berthou A, Blaise S, Fougerat A, Berge E, Montheil A, Malet N, Wymann MP, Maurice P, Debelle L, Martiny L, Martinez LO, Pshezhetsky AV, Duca L, Laffargue M.2014Cardiovasc Res.
24030815Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake.Pons V, Serhan N, Gayral S, Malaval C, Nauze M, Malet N, Laffargue M, Galés C, Martinez LO.2014Cell Mol Life Sci.
24472833Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation.Yao Q, Renault MA, Chapouly C, Vandierdonck S, Belloc I, Jaspard-Vinassa B, Daniel-Lamazière JM, Laffargue M, Merched A, Desgranges C, Gadeau AP.2014Blood
24476490Lack of P2Y13 in mice fed a high cholesterol diet results in decreased hepatic cholesterol content, biliary lipid secretion and reverse cholesterol transport.Lichtenstein L, Serhan N, Annema W, Combes G, Robaye B, Boeynaems JM, Perret B, Tietge UJ, Laffargue M, Martinez LO.2013Nutr Metab.
24074699Targeting high-density lipoproteins: update on a promising therapy.Verdier C, Martinez LO, Ferrières J, Elbaz M, Genoux A, Perret B.2013Arch Cardiovasc Dis.
23874450Association of hepatic lipase -514T allele with coronary artery disease and ankle-brachial index, dependence on the lipoprotein phenotype: the GENES study.Verdier C, Ruidavets JB, Bongard V, Taraszkiewicz D, Martinez LO, Elbaz M, Ferrières J, Perret B.2013PLoS One
23794714Serum IF1 concentration is independently associated to HDL levels and to coronary heart disease: the GENES study.Genoux A, Ruidavets JB, Ferrières J, Combes G, Lichtenstein L, Pons V, Laffargue M, Taraszkiewicz D, Carrié D, Elbaz M, Perret B, Martinez LO.2013J Lipid Res.
23266391Chronic pharmacological activation of P2Y13 receptor in mice decreases HDL-cholesterol level by increasing hepatic HDL uptake and bile acid secretion.Serhan N, Cabou C, Verdier C, Lichtenstein L, Malet N, Perret B, Laffargue M, Martinez LO.2013Biochim Biophys Acta.
23824069PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.Walser R, Burke JE, Gogvadze E, Bohnacker T, Zhang X, Hess D, Küenzi P, Leitges M, Hirsch E, Williams RL, Laffargue M, Wymann MP.2013 PLoS Biol.
23561795Elastin fragmentation and atherosclerosis progression: the elastokine concept.Maurice P, Blaise S, Gayral S, Debelle L, Laffargue M, Hornebeck W, Duca L.2013Trends Cardiovasc Med.
23055519Identification of the F1-ATPase at the cell surface of colonic epithelial cells: role in mediating cell proliferation.Kowalski-Chauvel A, Najib S, Tikhonova IG, Huc L, Lopez F, Martinez LO, Cohen-Jonathan-Moyal E, Ferrand A, Seva C2012J Biol Chem.
22251152Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration.Fougerat A, Smirnova NF, Gayral S, Malet N, Hirsch E, Wymann MP, Perret B, Martinez LO, Douillon M, Laffargue M.2012Br J Pharmacol.
21935367Mitochondrial inhibitory factor 1 (IF1) is present in human serum and is positively correlated with HDL-cholesterol.Genoux A, Pons V, Radojkovic C, Roux-Dalvai F, Combes G, Rolland C, Malet N, Monsarrat B, Lopez F, Ruidavets JB, Perret B, Martinez LO.2011PLoS One
21157968Ecto-F₁-ATPase: a moonlighting protein complex and an unexpected apoA-I receptor.Vantourout P, Radojkovic C, Lichtenstein L, Pons V, Champagne E, Martinez LO.2010Hepatology
26009456Cell surface F1-ATPase binds the Gastrin precursor, G-gly, and mediates its proliferative effects on colorectal cancer cells and vascular endothelial cells.Kowalski-Chauvel A, Najib S, Bertrand C, Martinez LO, Ferrand A, Seva C.2010Regul Pept.
20483757F1-adenosine triphosphatase displays properties characteristic of an antigen presentation molecule for Vgamma9Vdelta2 T cells.Mookerjee-Basu J, Vantourout P, Martinez LO, Perret B, Collet X, Périgaud C, Peyrottes S, Champagne E.2010J Immunol.