Microenvironment of Adipose Tissue
Adipose tissue is composed of adipose cells (adipocytes storing lipids under the form of triacylglycerol) and a stroma-vascular fraction (SVF) rich in progenitor, vascular and immune cells which play a key role in its pathophysiology. The work of our team aims at studying the key molecular and cellular mechanisms orchestrated by these SVF cells, as well as the extracellular matrix in physiological and pathological conditions such as during the progression of obesity-associated diseases and cancers.
Our research is based on the sorting of the different subsets of SVF cells derived from adipose tissue of different anatomical sites and on the development of in vivo, ex vivo and tissue approaches. These tools allow us to study the contribution of progenitor, endothelial and immune cells in the pathophysiology of adipose tissue.