Research axis

A monothematic center called "Institute of Cardiovascular and Metabolic Diseases" (I2MC) was established in January 2011 by INSERM and University Paul Sabatier.


The I2MC is a unique institute in France with teams working on risk factors and cardiovascular complications, including obesity, diabetes, dyslipidemia, thrombosis, atherosclerosis, angiogenesis, renal failure and heart.On April 19, 2011 inauguration of the Institute in the presence of Gilles Fourtanier President of the Paul Sabatier University , Jean Jacques Romatet Director of Toulouse Hospitals, Angelo Parini Executive Director of I2MC, Jean Tkaczuk representing the Regional Council of Midi Pyrenees, Dominique Langin Deputy Director of I2MC and Mireille Blanc Regional Delegate INSERM Midi Pyrenees.

The research activity developed at I2MC is centered on three main areas:

  • The axis adipose tissue, obesity and diabetes
  • The axis thrombosis, atherosclerosis and vessels
  • The axis heart and kidney

Magazine from Paul Sabatier University devoted to I2MC research


Latest publications

A reference measurement of circulating ATPase inhibitory factor 1 (IF1) in humans by LC-MS/MS: Comparison with conventional ELISA. (team 5)

PMID : 32887042 | Revue : Talanta

Auteurs : Genoux A, Duparc T, Ruidavets JB, Ingueneau C, Najib S, Ferrieres J, Perret B, Croyal M, Martinez...

Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation. (team 5)

PMID : 30821416 | Revue : Acta Physiol (Oxf).

Auteurs : Cabou C, Honorato P, Briceño L, Ghezali L, Duparc T, León M, Combes G, Frayssinhes ...

Serum level of High-density lipoprotein particles are independently associated with long-term prognosis in patients with coronary artery disease: The GENES study (team 5)

PMID : 32424189 | Revue : Sci Rep.

Auteurs : Duparc T, Ruidavets JB, Genoux A, Ingueneau C, Najib S, Ferrieres J, Perret B*, Martinez L.O*. Co...

Job offers

  • [CDD] Post-Doctorant

    (team 13)

    3 years position
    "Identify therapeutic target for lymphedema"

  • [CDD] IE

    (team 13)

    2 years postition.
    Gene therapy for lymphedema

  • [Doctorat] Doctorant

    (team 4)

    Lipid droplet hypertrophy: the link between adipocyte dysfunction and cardiometabolic diseases

  • [Doctorat] Doctorant

    (team 1)

    Metabolic function of adipose tissue microvasculature:
    a target of obesity and aging
    Thesis Position in _Endothelium and Metabolism_Toulouse France
    link :