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Team 2

FUNCTIONAL GENOMIC OF METABOLIC DISEASES


Understanding requires analyzing. The aim of our research is to decipher the molecular mechanisms controlling glycemia, lipidemia and heart remodeling. The corresponding findings will ensure the identification of novel biomarkers to predict, diagnose and classify as well as to validate nutritional and pharmacological therapeutic strategies for the control of diabetes, dyslipidemia and obesity as well as their co-morbidities such as heart failure and liver fibrosis.

We have been among the first to identify the role and novel mode of action of intestinal functions: the role of incretin secretion on the autonomic nervous system (gut brain periphery axis), the molecular handling of gut lipids, and intestinal immune defense. In addition, we evidenced the role of gut and mouth microbiota on the oral and intestinal adaptive and innate immune defense for the control of the translocation of bacteria and bacterial factors (metafactors) towards the tissues of the host to establish an internal tissue microbiota. The latter controls the tissue transcriptom and initiates metabolic inflammation for the development of metabolic diseases and heart remodeling.

These major scientific steps have been performed thanks to the development of innovative processes suitable for the physiological phenotyping of animal models, mathematical models, and original and unique animal models which enable us to generate novel molecular hypotheses and to validate their relevance. Eventually, thanks to close national and international collaborations with clinicians from our group we set up original data bases and clinical trials to translate the fundamental findings into clinical practice. The corresponding gain of knowledge are the basis of the funding of biotech companies with which we are closely collaborating and help us obtain large sets of results and novel methods for the development of our present future in science.

Altogether, our laboratory is a consortium of unique expertise in the field of microbiology, immunology, heart, metabolic and gastrointestinal physiology, epidemiology and mathematics in order to translate from clinical observation towards molecular understanding and benefit in humans.

Expected health effects

Identification of biomarkers causal to the diseases to predict, classify and diagnose diseases and co-morbidities.

Identification of functional targets and corresponding molecules suitable to the development of novel therapeutic strategies based on the control of intestinal functions.

Cooperation and Partnerships

European FP7: FLORINASH, Italy, Spain, Great Britain

Managers

Rémy BURCELIN






Xavier COLLET

Curriculum Vitae
Main publications






The team

AMAR Jacques (PU/PH)
AZALBERT Vincent (TN)
BLASCO Vincent (Doc)
BURCELIN Rémy (DR1)
CAMPISTRON Gérard (PU)
CHARPENTIER Julie (AI)
COLLET Xavier (DR2)
GARIDOU Lucile (Post doc)
GRASSET Estelle (Doc)
LOUBIERES Pascale (TN)
MOREAU Jacques (PH)
POMIE Celine (Post doc)
PUEL Anthony (AI)
SERINO Matteo (Post doc)
SIMON Nicolas (Doc)
SRENG Navin (Doc)
TERCE François (CR1)
WAGET Aurélie (AI)


Picture legend














Role of intestinal microbiota

Date of update December 2, 2014


Version Française


Contact

Rémy BURCELIN
Tél : 05 61 32 56 14
Fax : 05 61 32 56 21
e-mail : remy.burcelin@inserm.fr
Address :
Inserm/UPS  UMR 1048 - I2MC, Equipe 2
1 avenue Jean Poulhès
BP 84225
31432 Toulouse Cedex 4

Keywords


Diabetes
Fonctionnal exploration
Obesity
Metabolic diseases
Insulin resistance
Autonomous nervous system
Vascular bloor flow
Inflammation
Intestinal microbiota
GLP-1 signaling
Intestinal absorption
Animal models

Biological ressources


Liver gene expression, metagenomic in feces (Patients NAFLD)
Diabetes and obesity animal models
CACO2 cells
Intestinal  lipid transport

Methodologies used


- State of the art techniques unique in France to study in vivo in the awake free moving mouse glucose
(tracers) and vascular homeostasis (ultrasonic probe) simultaneously with brain infusate to respect the
integrity of the physiological systems and to address molecular issues.
- Vagus nerve recording.
- Blood hormone biochemistry.
- Metagenomique, bioinformatique, metafactors secretome (secreted bacterial product library)
- Accurate immunological phenotyping (FACS, lymphocyte transfer, confocal analyses...)
- Lipidology, enteric cell culture, molecular fluorescent tools for the analysis of lipid handing

Picture library

Unité 1048 ou I2MC -Institut des Maladies Métaboliques et Cardiovasculaires, 1 avenue Jean Poulhès - BP 84225, 31432 Toulouse Cedex 4
Inserm Université de Toulouse Université Toulouse III - Paul Sabatier